Palmar plantar erythrodysesthesia causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Several different Chemotherapeutic agents have been associated with acral erythema[1]
Causes
Chemotherapy drugs that can cause this syndrome include:
Most frequently associated:
- Cytarabine13,14 (Cytosar-U)
- Docetaxel15,16 (Docefrez, Taxotere)
- Doxorubicin (Adriamycin)17,18 and liposomal-encapsulated doxorubicin19-25 (Doxil)
- 5-Fluorouracil26-41 (5-FU, Adrucil)
- Capecitabine8,42-47 (Xeloda)
- Sorafenib [2]
Less frequently associated:
- Cisplatin48
- Cyclophosphamide49
- Daunorubicin and liposomal daunorubicin50
- Doxifluridine
- Etoposide51-54
- Floxuridine55 (FUDF)
- Hydroxyurea56,57 (hydroxycarbamide)
- 6-Mercaptopurine9
- Methotrexate58-63
- Mitotane1
- Paclitaxel64-67 (Taxol)
- Tegafur68-70
- Vinorelbine71-74
- Idarubicin (Idamycin)
- Vemurafenib75 (Zelboraf)
- 6-thioguanine76
Commonly associated chemotherapeutic agents are listed below:
- Most frequently associated with Doxorubicin (Pegylated liposomal Doxorubicin), 5-Flurouracil, and Cytarabine[3].
- Methotrexate - even low dose used to treat ALL[4]
- Mitotane[5]
- PLD, Docetaxel, Capecitabine, vinorelbine, gemcitabine and Sorafenib[2]
Less Common Causes[6]
- Cisplatin
- Cyclophosphamide
- Daunorubicin
- Doxifluridine
- Etoposide
- Floxuridine
- Hydroxyurea
- Idarubicin
- Lomustine
- Melphalan
- Mercaptopurine
- Mitomycin
- Paclitaxel
- Suramin
- Troxacitabine[7]
- Tegafur
- Vincristine
Genetics
No genetic association has been found as of yet as the data on this condition is limited.
References
- ↑ Baack BR, Burgdorf WH (1991). "Chemotherapy-induced acral erythema". J Am Acad Dermatol. 24 (3): 457–61. PMID 2061446.
- ↑ 2.0 2.1 Farr KP, Safwat A (2011). "Palmar-plantar erythrodysesthesia associated with chemotherapy and its treatment". Case Rep Oncol. 4 (1): 229–35. doi:10.1159/000327767. PMC 3085037. PMID 21537373.
- ↑ Webster-Gandy JD, How C, Harrold K (2007). "Palmar-plantar erythrodysesthesia (PPE): a literature review with commentary on experience in a cancer centre". Eur J Oncol Nurs. 11 (3): 238–46. doi:10.1016/j.ejon.2006.10.004. PMID 17350337.
- ↑ Wysocki M, Nowaczyk-Michalak A, Pilecki O, Kurylak A, Balcar-Boroń A, Trybuś L (1992). "[Burgdorf's reaction (painful acral erythema) in patients with acute lymphoblastic leukemia following medium-dose methotrexate therapy]". Wiad Lek. 45 (11–12): 462–4. PMID 1441532.
- ↑ Zuehlke RL (1974). "Erythematous eruption of the palms and soles associated with mitotane therapy". Dermatologica. 148 (2): 90–2. PMID 4276191.
- ↑ Susser WS, Whitaker-Worth DL, Grant-Kels JM (1999). "Mucocutaneous reactions to chemotherapy". J Am Acad Dermatol. 40 (3): 367–98, quiz 399-400. PMID 10071309.
- ↑ Hidalgo M, Siu LL, Nemunaitis J, Rizzo J, Hammond LA, Takimoto C; et al. (2001). "Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies". J Clin Oncol. 19 (13): 3267–79. doi:10.1200/JCO.2001.19.13.3267. PMID 11432895.