Macrocytic anemia natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of megaloblastic anemia include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of megaloblastic anemia typically develop ___ years after exposure to ___.
- If left untreated, [#]% of patients with megaloblastic anemia may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
- Common complications of megaloblastic anemia include:[1]
- Subacute combined degeneration of spinal cord
- Pyrexia of unknown origin[2]
- Damage to the nervous system
- Long-term neurologic complications.
- Peripheral neuropathy
- Dementia.
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with megaloblastic anemia is approximately [--]%.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
References
- ↑ Aslinia F, Mazza JJ, Yale SH (September 2006). "Megaloblastic anemia and other causes of macrocytosis". Clin Med Res. 4 (3): 236–41. PMC 1570488. PMID 16988104.
- ↑ Siddiqui B, Rabindranath D, Faridi SH, Khan AA, Haiyat S, Eswaran R (2015). "Megaloblastic anemia: A common but often neglected cause of pyrexia of unknown origin". J Transl Int Med. 3 (2): 64–67. doi:10.1515/jtim-2015-0005. PMC 4936446. PMID 27847889.