Myelofibrosis historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2], Sujit Routray, M.D. [3]
Overview
The first description of primary myelofibrosis (PMF) is credited to a German surgeon, Gustav Heuck. He described the concept in 1879 under the title of ‘Two cases of leukemia with peculiar blood and bone marrow findings’. Heuck described two patients with massive splenomegaly, increased number of morphologically abnormal leukocytes, and nucleated red blood cells. He observed that the clinical findings in these two patients were different from those described for chronic myelogenous leukemia (CML) because of the presence of marrow fibrosis and extensive extramedullary hematopoiesis (EMH).
Historical Perspective
- Myelofibrosis was first discribed by Gustav Heuck, a German surgeon, in 1879, under the title of 'Two cases of leukemia with peculiar blood and bone marrow findings'.[1]
- The concept of myeloproliferative disorders (MPDs) was described by William Dameshek, in 1951, by bringing together these five clinicopathologic entities: chronic myelogenous leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), and erythroleukemia.[1]
- The World Health Organization utilizes the name "chronic idiopathic myelofibrosis", while the International Working Group on Myelofibrosis Research and Treatment calls the disease "primary myelofibrosis".[2]
References
- ↑ 1.0 1.1 Tefferi, A (2007). "The history of myeloproliferative disorders: before and after Dameshek". Leukemia. 22 (1): 3–13. doi:10.1038/sj.leu.2404946. ISSN 0887-6924.
- ↑ History of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 7, 2016