Polycythemia vera history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]; Shyam Patel [3]

Overview

People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include headache, fatigue, and pruritis. The symptomatology is highly variable between patients. Some patients can present with a minimal symptom burden that does not result in any change in quality of life, and other patients can have severe symptom burden.

History and Symptoms

Symptoms of polycythemia vera are related to the consequences of excess red blood cells. These symptoms may include:

• Headache
• Pruritis

• Especially after exposure to warm water
• Due to histamine release or prostaglandin production
• Present in approximately 40% of patients

• Tinnitis
• Blurred vision
• Malaise
• Loss of appetite
• Weight loss
• Shortness of breath
• Fatigue
• Dizziness
• Bleeding

• Bruising
• Epistaxis
• Bleeding gums
• Menorrhagia
• Metrorrhagia
• Petechiae

• Chest pain
• Arthralgia
• Erythromelalgia
• Heart burn

• Due to increased susceptibility to infection with H. pylori

History[edit | edit source] Patients with [disease name]] may have a positive history of:

[History finding 1] [History finding 2] [History finding 3] Common Symptoms[edit | edit source] Common symptoms of polycythemia vera include:Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK, Abboud CN, Adler K, Heaney ML, Jabbour EJ, Komrokji RS, Moliterno AR, Ritchie EK, Rice L, Mascarenhas J, Hoffman R (November 2015). "Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F". J. Clin. Oncol. 33 (33): 3953–60. doi:10.1200/JCO.2015.61.6474. PMC 4979103. PMID 26324368.

• Fatigue
• Headache
• Insomnia
• Decreased mood
• Numbness
• Early satiety
• Itching
• Loss of concentration
• Night sweats
• Sexual problems
• Dizziness
• Cough
• Bone pains
• Abdominal pain

References

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