Polycythemia vera history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]; Shyam Patel [3]

Overview

People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include headache, fatigue, and pruritis. The symptomatology is highly variable between patients. Some patients can present with a minimal symptom burden that does not result in any change in quality of life, and other patients can have severe symptom burden.

History and Symptoms

Symptoms of polycythemia vera are related to the consequences of excess red blood cells. These symptoms may include:

• Headache
• Pruritis

• Especially after exposure to warm water
• Due to histamine release or prostaglandin production
• Present in approximately 40% of patients

• Tinnitis
• Blurred vision
• Malaise
• Loss of appetite
• Weight loss
• Shortness of breath
• Fatigue
• Dizziness
• Bleeding

• Bruising
• Epistaxis
• Bleeding gums
• Menorrhagia
• Metrorrhagia
• Petechiae

• Chest pain
• Arthralgia
• Erythromelalgia
• Heart burn

• Due to increased susceptibility to infection with H. pylori

History and Symptoms

• The majority of patients with [disease name] are asymptomatic.

OR

• The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
• Symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].

History

Patients with [disease name]] may have a positive history of:

• [History finding 1]
• [History finding 2]
• [History finding 3]

Common Symptoms

Common symptoms of polycythemia vera include:

• Fatigue
• Headache
• Abdominal pain
• Loss of concentration
• Night sweats
• Sexual problems
• Insomnia
• Decreased mood
• Numbness
• Early satiety
• Dizziness
• Cough
• Bone pains

Less Common Symptoms

Less common symptoms of polycythemia vera include

• Fever
• Weight loss

References

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