Glanzmann's thrombasthenia secondary prevention
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Glanzmann's thrombasthenia |
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Differentiating Glanzmann's thrombasthenia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2], Niyousha Danesh, MD-MPH
Overview
Glanzmann’s thrombasthenia patients need regular dental visits and must maintain good oral hygiene because the recurrence of gingival bleeding is more in them. These patient should avoid contact sports. Women with GT, because of menorrhagia, should be monitored regularly for iron deficiency anemia and if needed, should receive iron supplements.
85 % of patients with Glanzmann’s thrombasthenia require at least once in their lifetime blood transfusion, so they should be immunized against hepatitis B.
GT patients should not use non-steroidal anti-inflammatory drugs(NSAID) and aspirin.
GT Patients require HLA typing at the time of diagnosis, and should be monitored for HLA and anti-platelet antibodies. Patients should be educated,how to control bleeding from a minor wound or epistaxis by means of pressure or taking an oral anti-fibrinolytic drug ,and they should approach a medical professional in the case of uncontrolled bleeding.
Secondary Prevention
DDAVPprevents bleeding after dental extraction and minor surgery in patients with milder platelet defects[1][2] Glanzmann’s thrombasthenia patients need regular dental visits and must maintain good oral hygiene because the recurrence of gingival bleeding is more in them.
These patient should avoid contact sports.
Women with GT, because of menorrhagia, should be monitored regularly for iron deficiency anemia and if needed, should receive iron supplements.
85 % of patients with Glanzmann’s thrombasthenia require at least once in their lifetime blood transfusion, so they should be immunized against hepatitis B.
GT patients should not use non-steroidal anti-inflammatory drugs(NSAID) and aspirin.
GT Patients require HLA typing at the time of diagnosis, and should be monitored for HLA and anti-platelet antibodies.
Patients should be educated,how to control bleeding from a minor wound or epistaxis by means of pressure or taking an oral anti-fibrinolytic drug ,and they should approach a medical professional in the case of uncontrolled bleeding.
References
- ↑ Piot B, Sigaud-Fiks M, Huet P, Fressinaud E, Trossaërt M, Mercier J (March 2002). "Management of dental extractions in patients with bleeding disorders". Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 93 (3): 247–50. PMID 11925531.
- ↑ Kosch A, Kehrel B, Nowak-Göttl U, Häberle J, Jürgens H (1999). "[Thrombocytic alpha-delta-storage-pool-disease: shortening of bleeding time after infusion of 1-desamino-8-D-arginine vasopressin]". Klin Padiatr (in German). 211 (4): 198–200. doi:10.1055/s-2008-1043787. PMID 10472549.