Polycythemia vera history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]; Shyam Patel [3]
Overview
People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include headache, fatigue, and pruritis. The symptomatology is highly variable between patients. Some patients can present with a minimal symptom burden that does not result in any change in quality of life, and other patients can have severe symptom burden.
History and Symptoms
History
Patients with polycythemia vera may have a positive history of:[1]
- Pruritus
- Fatigue
- Headache
- Early satiety
Common Symptoms
Common symptoms of polycythemia vera include:[2][1]
- Fatigue
- Headache
- Pruritus
- Especially after exposure to warm water
- May be related to serotonin release by platelets as well as elevated histamine levels
- Abdominal pain
- Loss of concentration
- Night sweats
- Sexual problems
- Insomnia
- Decreased mood
- Numbness
- Early satiety
- Dizziness
- Cough
- Erythromelalgia
- Weakness
Less Common Symptoms
Less common symptoms of polycythemia vera include[2]
- Fever
- Weight loss
- Sweating
- Visual disturbances
- Parasthesias
- Dyspnea
- Bone pains
References
- ↑ 1.0 1.1 Tefferi, A. (2002). "Selective serotonin reuptake inhibitors are effective in the treatment of polycythemia vera-associated pruritus". Blood. 99 (7): 2627–2627. doi:10.1182/blood.V99.7.2627. ISSN 0006-4971.
- ↑ 2.0 2.1 Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK, Abboud CN, Adler K, Heaney ML, Jabbour EJ, Komrokji RS, Moliterno AR, Ritchie EK, Rice L, Mascarenhas J, Hoffman R (November 2015). "Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F". J. Clin. Oncol. 33 (33): 3953–60. doi:10.1200/JCO.2015.61.6474. PMC 4979103. PMID 26324368.