UTY (gene)

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	Wikidata
View/Edit Human

Histone demethylase UTY is an enzyme that in humans is encoded by the UTY gene.^[1]^[2]^[3]

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.^[3]

Interactions

UTY (gene) has been shown to interact with TLE1,^[4] and WDR90^[5]

References

↑ Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, Simpson E, Koopman P (Jan 1997). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene". Nat Genet. 14 (4): 474–478. doi:10.1038/ng1296-474. PMID 8944031.
↑ Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P (May 1998). "The UTX gene escapes X inactivation in mice and humans". Hum Mol Genet. 7 (4): 737–742. doi:10.1093/hmg/7.4.737. PMID 9499428.
↑ ^3.0 ^3.1 "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked".
↑ Grbavec, D; Lo R; Liu Y; Greenfield A; Stifani S (Jan 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". Biochem. J. ENGLAND. 337 (1): 13–7. doi:10.1042/0264-6021:3370013. ISSN 0264-6021. PMC 1219929. PMID 9854018.
↑ "STRING: functional protein association networks". string-db.org. Retrieved 2015-05-07.

Lahn BT, Page DC (1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–680. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
Grbavec D, Lo R, Liu Y, et al. (1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". Biochem. J. 337 (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
Warren EH, Gavin MA, Simpson E, et al. (2000). "The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen". J. Immunol. 164 (5): 2807–14. doi:10.4049/jimmunol.164.5.2807. PMID 10679124.
Foresta C, Ferlin A, Moro E (2000). "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility". Hum. Mol. Genet. 9 (8): 1161–1169. doi:10.1093/hmg/9.8.1161. PMID 10767340.
Shen P, Wang F, Underhill PA, et al. (2000). "Population genetic implications from sequence variation in four Y chromosome genes". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7354–7359. Bibcode:2000PNAS...97.7354S. doi:10.1073/pnas.97.13.7354. PMC 16549. PMID 10861003.
Vogt MH, Goulmy E, Kloosterboer FM, et al. (2000). "UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition". Blood. 96 (9): 3126–32. PMID 11049993.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–569. doi:10.1038/nbt810. PMID 12665801.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–837. Bibcode:2003Natur.423..825S. doi:10.1038/nature01722. PMID 12815422.
Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–396. doi:10.1093/molbev/msh027. PMID 14660691.
Gerrard DT, Filatov DA (2005). "Positive and negative selection on mammalian Y chromosomes". Mol. Biol. Evol. 22 (6): 1423–1432. doi:10.1093/molbev/msi128. PMID 15758204.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[pmid8944031-1] Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, Simpson E, Koopman P (Jan 1997). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene". Nat Genet. 14 (4): 474–478. doi:10.1038/ng1296-474. PMID 8944031.

[pmid9499428-2] Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P (May 1998). "The UTX gene escapes X inactivation in mice and humans". Hum Mol Genet. 7 (4): 737–742. doi:10.1093/hmg/7.4.737. PMID 9499428.

[entrez-3] 3.0 ^3.1 "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked".

[pmid9854018-4] Grbavec, D; Lo R; Liu Y; Greenfield A; Stifani S (Jan 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". Biochem. J. ENGLAND. 337 (1): 13–7. doi:10.1042/0264-6021:3370013. ISSN 0264-6021. PMC 1219929. PMID 9854018.

[5] "STRING: functional protein association networks". string-db.org. Retrieved 2015-05-07.

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UTY (gene)

Interactions

References

Further reading

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