Thymidine kinase 2, mitochondrial

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External IDs	GeneCards: [1]
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	Wikidata
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Thymidine kinase 2, mitochondrial is a protein that in humans is encoded by the TK2 gene.^[1]

Function

This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria.

This kinase is not present in yeast.^[2]

References

↑ "Entrez Gene: Thymidine kinase 2, mitochondrial".
↑ Zeman L, Lusena CV (March 1974). "DNA precursors and the absence of thymidine kinase in yeast mitochondria". FEBS Letters. 40 (1): 84–7. doi:10.1016/0014-5793(74)80899-9. PMID 4604357.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[entrez-1] "Entrez Gene: Thymidine kinase 2, mitochondrial".

[2] Zeman L, Lusena CV (March 1974). "DNA precursors and the absence of thymidine kinase in yeast mitochondria". FEBS Letters. 40 (1): 84–7. doi:10.1016/0014-5793(74)80899-9. PMID 4604357.

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[2]

Thymidine kinase 2, mitochondrial

Function

References

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