DNA polymerase nu

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Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
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UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene. It is a family A DNA polymerase, considered to be the least effective of the polymerase enzymes. However, DNA polymerase nu plays an active role in homology repair during cellular responses to crosslinks, fulfilling its role in a complex with helicase.

Further reading

• Zietlow L, Smith LA, Bessho M, Bessho T (December 2009). "Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links". Biochemistry. 48 (49): 11817–24. doi:10.1021/bi9015346. PMC 2790558. PMID 19908865.
• Bi X, Barkley LR, Slater DM, Tateishi S, Yamaizumi M, Ohmori H, Vaziri C (May 2006). "Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest". Molecular and Cellular Biology. 26 (9): 3527–40. doi:10.1128/MCB.26.9.3527-3540.2006. PMC 1447421. PMID 16611994.
• Moldovan GL, Madhavan MV, Mirchandani KD, McCaffrey RM, Vinciguerra P, D'Andrea AD (February 2010). "DNA polymerase POLN participates in cross-link repair and homologous recombination". Molecular and Cellular Biology. 30 (4): 1088–96. doi:10.1128/MCB.01124-09. PMC 2815579. PMID 19995904.
• Marini F, Kim N, Schuffert A, Wood RD (August 2003). "POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308". The Journal of Biological Chemistry. 278 (34): 32014–9. doi:10.1074/jbc.M305646200. PMID 12794064.
• Arana ME, Takata K, Garcia-Diaz M, Wood RD, Kunkel TA (February 2007). "A unique error signature for human DNA polymerase nu". DNA Repair. 6 (2): 213–23. doi:10.1016/j.dnarep.2006.09.012. PMC 1950682. PMID 17118716.
• Göhler T, Sabbioneda S, Green CM, Lehmann AR (January 2011). "ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage". The Journal of Cell Biology. 192 (2): 219–27. doi:10.1083/jcb.201008076. PMC 3172178. PMID 21242293.
• Yamanaka K, Minko IG, Takata K, Kolbanovskiy A, Kozekov ID, Wood RD, Rizzo CJ, Lloyd RS (March 2010). "Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links". Chemical Research in Toxicology. 23 (3): 689–95. doi:10.1021/tx900449u. PMC 2838406. PMID 20102227.
• Arana ME, Potapova O, Kunkel TA, Joyce CM (November 2011). "Kinetic analysis of the unique error signature of human DNA polymerase ν". Biochemistry. 50 (46): 10126–35. doi:10.1021/bi201197p. PMC 3235957. PMID 22008035.