Astrocytoma differential diagnosis

Astrocytoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.

Differentiating astrocytoma from other Diseases

Diseases		Clinical manifestations								Para-clinical findings					Gold standard	Additional findings
		Symptoms					Physical examination
										Lab Findings		Imaging		Histopathology
		Headache	Seizure	Visual disturbance	Hearing loss	Constitutional	Extraocular movement disorder	Hydrocephalus	Focal neurologic deficit	EPO	Prolactin	CT scan	MRI
Adult primary brain tumors	Glioblastoma multiform	+						−	+					Astrocyte origin Pleomorphic cell Pseudopalisading appearance GFAP+ Necrosis+ Hemorrhage+ Vascular prolifration+
	Oligodendroglioma	+						−	+					Oligodendrocyte origin Calcification+ Fried egg cell appearance
	Meningioma	+						−	+					Arachnoid origin Psammoma bodies Whorled spindle cell pattern
	Hemangioblastoma	+						−	+	+				Blood vessel origin Capillaries with thin walls
	Pitutary adenoma	+		+ Bitemporal hemianopia				−	−		+/−
	Schwannoma	+			+			−
	primary CNS lymphoma	+						−
Childhood primary brain tumors	Pilocytic astrocytoma	+						−
	Medulloblastoma	+						+
	Ependymoma	+						+
	Craniopharyngioma	+		+ Bitemporal hemianopia				−
	Pinealoma	+					+ vertical gaze palsy	−
Vascular	AV malformation	+						−
	Brain aneurysm	+						−
Infectious	Bacterial brain abscess	+				+		−
	Tuberculosis	+				+		−
	Toxoplasmosis	+						−
	Hydatid cyst	+						−
	Fungal	+						−
Other	Brain metastasis	+						−