Non-Hodgkin lymphoma biopsy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]

Overview

Lymph node or extranodal tissue biopsy is diagnostic of non-Hodgkin lymphoma.

Lymph node or extranodal tissue biopsy is diagnostic of non-Hodgkin lymphoma.^[1]^[2]^[3]^[4]
Biopsy findings vary in morphologic features depending on the specific subtype.
The abnormal lymphocytes in the lymph node, bone marrow, or extranodal sites can be subdivided as small cleaved or noncleaved, intermediate, or large cell and can have a follicular or diffuse pattern.
Lymphomas usually alter the lymph node architecture, and the capsule is usually involved.

↑ Intragumtornchai T, Bunworasate U, Wudhikarn K, Lekhakula A, Julamanee J, Chansung K; et al. (2018). "Non-Hodgkin lymphoma in South East Asia: An analysis of the histopathology, clinical features, and survival from Thailand". Hematol Oncol. 36 (1): 28–36. doi:10.1002/hon.2392. PMID 28332735.
↑ Casulo C, Burack WR, Friedberg JW (2015). "Transformed follicular non-Hodgkin lymphoma". Blood. 125 (1): 40–7. doi:10.1182/blood-2014-04-516815. PMID 25499449.
↑ Bain BJ, Clark DM, Lampert IA, Wilkins BS, editors. Bone marrow pathology. 3 rd ed. UK: Blackwell Science Ltd; 2001.
↑ Bartl R, Frisch B, Burkhardt R, Jδger K, Pappenberger R, Hoffmann-Fezer G. Lymphoproliferations in bone marrow: i0 dentification and evaluation, classification and staging. J Clin Pathol 1984;37:233-54.