Merkel cell cancer other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Other diagnostic studies for merkel cell cancer include skin biopsy, which demonstrates positive cytokeratin-20 , and electron microscopy, which demonstrates granules, and cytoplasmic extensions
Other Diagnostic Studies
Skin biopsy
Skin biopsy may be helpful in the diagnosis of merkel cell cancer. Findings diagnostic of merkel cell cancer include
- The histopathological diagnosis of merkel cell cancer is difficult, and the majority of cases with merkel cell cancer are often misdiagnosed.
- On skin biopsy, merkel cell cancer is characterized by positive staining on cytokeratin-20 immunohistochemical assay.[1]
Electron microscopy
- On electron microscopy, merkel cell cancer is characterized by the presence of
- Neurosecretory granules within cytoplasmic extensions.[1]
References
- ↑ 1.0 1.1 Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF; et al. (2008). "Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features". J Am Acad Dermatol. 58 (3): 375–81. doi:10.1016/j.jaad.2007.11.020. PMC 2335370. PMID 18280333.