Appendix cancer surgery
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Soroush Seifirad, M.D.[2]
Overview
Surgery is the mainstay of treatment for appendix cancer. The feasibility as well as determining the appropriate plan of surgery depends on the stage of appendix cancer at diagnosis.
Surgery
- Surgery is the mainstay of treatment for appendix cancer.
- The feasibility as well as determining the appropriate plan of surgery depends on the stage of appendix cancer at diagnosis.
- Carcinoid tumors are generally treated with appendectomy, right hemicolectomy and surrounding lymph nodes dissection.
- Non-carcinoid tumors are candied for tumor debulking surgery; in addition to right hemicolectomy and tumor dissection (also called cytoreductive surgery), gallbladder, as well ovaries and uterus in female patients might be excised. Tumor debulking surgery might accompanied by hyperthermic intraperitoneal chemotherapy (HIPEC), specially in high stage cases with peritoneal seeding as well as in patients with pseudomyxoma peritonei.
- Approach to appendiceal carcinoid tumors
- Tumor size plays the critical role in surgical planning for the patients with appendix carcinoid tumors.
- Patients with tumors larger than 2 cm should undergo right hemicolectomy. [1]
- It has been controversial weather patients with smaller tumors benefit from right hemicolectomy or not? Although the Mayo Clinic study on 120 patients suggested appendectomy as the sufficient intervention in tumors smaller than 2 cm, but recent studies raised some concerns in this regard; indeed a higher potential for metastatic disease and lymph node metastasis has been demonstrated in new reports as well as SEER database, specially in mesoappendical invasion. [2][3][4]
- Europian Neuroendocrine Tumor Society (ENETS) and North American Neuroendocrine Tumor Society (NANETS) consensus based guideline suggests right hemicolectomy for tumors between 1 and 2 cm in the presence of deep mesoappendiceal invasion, positive or uncertain margins, high proliferation rate, angioinvasion and mixed histology ( adenocarcionid, goblet cell cacionid). [5][6]
- For tumors smaller than 1 cm, simple appendectomy is adequate.
- Approach to mucinous adenocarcinoma of the appendix[7]
- First determine weather the tumor is ruptured or not?<math>\blacktriangledown</math>
- If not ruptured determine the grade <math>\blacktriangledown</math>
- Right hemicolectomy with lymph node dissection is the appropriate approach for high grade tumors
- In low grade tumors appendectomy would be enough
- If the tumor is ruptured <math>\blacktriangledown</math>
- In gross peritoneal disease imaging to evaluate eligibility for complete cytoreduction is warranted, and if it was feasable cytoreduction and HIPEC is recommended.[8]
- In microscopic rupture the tumor grade plays the determinant role:<math>\blacktriangledown</math>
- laporoscopic evaluation and resection of the residual tumor is recommended for low grade tumors.
- High grade tumors should be treated with laparotomy, residual tumor removal, right hemicolectomy, omentectomy, right lower quadrant peritonectomy, plus bilateral oophorectomy in female patients, followed by HIPEC.
References
- ↑ Moertel CG, Weiland LH, Nagorney DM, Dockerty MB (1987) Carcinoid tumor of the appendix: treatment and prognosis. N Engl J Med 317 (27):1699-701. DOI:10.1056/NEJM198712313172704 PMID: 3696178
- ↑ Mullen JT, Savarese DM (2011) Carcinoid tumors of the appendix: a population-based study. J Surg Oncol 104 (1):41-4. DOI:10.1002/jso.21888 PMID: 21294132
- ↑ Roggo A, Wood WC, Ottinger LW (1993) Carcinoid tumors of the appendix. Ann Surg 217 (4):385-90. PMID: 8466309
- ↑ Syracuse DC, Perzin KH, Price JB, Wiedel PD, Mesa-Tejada R (1979) Carcinoid tumors of the appendix. Mesoappendiceal extension and nodal metastases. Ann Surg 190 (1):58-63. PMID: 464679
- ↑ Pape UF, Perren A, Niederle B, Gross D, Gress T, Costa F et al. (2012) ENETS Consensus Guidelines for the management of patients with neuroendocrine neoplasms from the jejuno-ileum and the appendix including goblet cell carcinomas. Neuroendocrinology 95 (2):135-56. DOI:10.1159/000335629 PMID: 22262080
- ↑ Boudreaux JP, Klimstra DS, Hassan MM, Woltering EA, Jensen RT, Goldsmith SJ et al. (2010) The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the Jejunum, Ileum, Appendix, and Cecum. Pancreas 39 (6):753-66. DOI:10.1097/MPA.0b013e3181ebb2a5 PMID: 20664473
- ↑ Kelly KJ (2015) Management of Appendix Cancer. Clin Colon Rectal Surg 28 (4):247-55. DOI:10.1055/s-0035-1564433 PMID: 26648795
- ↑ Low RN, Barone RM (2012) Combined diffusion-weighted and gadolinium-enhanced MRI can accurately predict the peritoneal cancer index preoperatively in patients being considered for cytoreductive surgical procedures. Ann Surg Oncol 19 (5):1394-1401. DOI:10.1245/s10434-012-2236-3 PMID: 22302265