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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]

Vaginal/Vulvar mass differential diagnosis

Diseases Clinical manifestations Para-clinical findings Gold standard
Symptoms Physical exam Lab Findings Imaging Histopathology
Abnormal

vaginal bleeding

Abnormal vaginal dyscharge Pelvic

pain

Itching or

burning of the vulva

Other Genitourinary/ Gastrointestinal symptoms B symptoms Abdominal pain Gynecological examinations Abdominal

mass

HPV Pap smear STI Panel Ultrasound MRI CT Scan
Cervical cancer[1][2][3][4][5][6] + + + +

+

+ ± ±Chlamydia T2-weighted MRI :
  • Ovoid, heterogeneous tumor distending the cervical canal with stromal involvement.
PET/CT scan:
Cervical polyp[7]
  • Postcoital
  • Intermenstrual
  • Postmenopausal
  • Bleeding after exam
+
  • Mass on exam
  • Hyper/hypoechogenic masses with or without cysts
  • Filling the endocervical or vaginal canal
  • Epithelial cells with no nuclear atypia/mitoses
  • Hysteroscopy /Biopsy
Cervical leiomyoma[8][9][10][11][12][13][14][15]
  • Heavy/prolonged menstrual bleeding
  • Intermenstrual bleeding
+ +
  • Urinary retention
  • Constipation
  • Infertility
  • Bowel obstruction
  • Increase in pregnancy/labor complications
+
  • Large,irregular pelvic mass
±
  • Well circumscribed hyperechoic mass
T2-weighted MRI:
  • Hypointense masses
  • Homogeneous

enhancement

  • Red degeneration
  • Spindle shaped smooth muscle cells
  • Mature adipocytes
  • Extracellular matrix consist of collagen,fibronectin.
  • Clinical diagnosis/ and
  • Ultrasound
Cervical lymphoma[16][17]
  • Postmenopausal bleeding
+
  • Difficulty urinating
  • Post-coital pain
+ +
  • Larrge uterine/cervix mass
  • Irregularity
+
  • Well-defined, solid, concentric, hypoechoic mass
  • Small tumor cells with large nuclei
  • High mitoses and proliferation
  • Biopsy
Cervical sarcoma[18]
  • Intermentrual
  • Postmenopausal
± +
  • Post-coital pain
  • Fullness in pelvic
± +
  • Cervical mass
  • Lump protruding from vagina/vulva
+
  • Biopsy
Cervical erosion(Ectropion)[19][20][21]
  • Light bleeding after pelvic exam
  • Spotting
+ + ±
  • Post-coital pain
  • Painful cramps
  • Pain after sex
+
Cervicitis[22][23]
  • Intermenstrual bleeding
  • Postcoital
  • Bleeding after pelvic exam
+ +
  • Itching
  • Pain during urination
  • Pain during sex
  • Painful menstruation
  • May have fever only
  • Red,inflammed swollen cervix
  • Inflammation/irritation of vulva/vagina
  • Chlamydia
  • Gonorrhea
  • Herpes simplex
  • Trichomonas vaginalis
IUD use[24]
  • Heavy bleeidng
± +
  • Itching
  • Painful menstruation
±
Pelvic inflammatory diseases[25]
  • Bleeding after sex
  • Intermenstrual bleeding
+ +
  • Itching/burning
  • Pain during sex
  • Painful menstruation
  • Burning sensation during urination
  • Pain during bowel movement
  • Fever
±Abdominal

pain

  • Pelvic pain
  • Vaginal/vulvar tender lesion depending on microbial cause
  • Chlamydia
  • Gonorrhea
Endometriosis[26][27][28][29]
  • Heavy mentrual bleeding
±
  • Pelvic pain
  • Back pain
  • Painful menstruation
  • Burning/painful urination
  • Painful bowel movement
  • Pain during or after sex
  • Infertility
+
  • Tender uterosacral nodularity
  • Immobile uterus
  • Cervical motion tenderness
  • Retroverted uterus
  • Visual inspection by laparascopy
Adenomyosis[30]
  • Abnormal uterine bleeding
+
  • Painful menstruation
  • Polypoid mass protruding into the endocervical canal.
Cervical ectopic pregnancy[31]
  • Amennorhea
  • Bleeding after pelvic exam
  • Pelvic pain
+
  • Soft and disporportionally enlarged uterus.
  • Empty uterine
  • Thickened endometrium
T2-weighted MRI:
  • Hypointense large mass

T1-weighted MRI:

  • Partially hyperintense mass
  • Necrotic hemorrhagic mass with chorionic villus
  • Hysterectomy and biopsy
DES exposure (Clear cell adenocarcinoma)[32]
  • Postcoital bleeding
+
Paget's disease of vulva to cervix[33][34][35]
  • Bleeding from lesion
  • Oozing
±
  • Itching/burning
  • Pain in vulva
  • Scaly eczematoid lesion in vulva.
  • Erythematous plaques with white scaling.
  • Inguinal lymphadenopathy in case of metastases.
  • Intraepidermal adenocarcinoma which involves epidermis
  • Biopsy of lesion
Vaginal cancer[36]
  • Postcoital bleeding

+

  • Tenesmus
  • Dysuria
  • Urinary frequency
  • Constipation
  • Pelvic pain
  • Vaginal lump
  • Inguinal lymphadenopathy
Nabothian cyst[37][38][39]
  • Postcoital bleeding
+
  • Pain during sex
  • Cystic mass on exam
  • Intermediate or slightly high signal intensity on T1-weighted
  • High signal intensity on T2-weighted images
Rectal cancer[40][41][42][43][44] - - + -
  • Constipation/diarrhea
  • Absent bowel sounds
  • Rectal mass/bleeding
  • Abdominal tenderness
Weight loss + LLQ + NL + - - +/- Endoscopic/transrectal US detects tumor extent Determine tumor stage Determine tumor stage
  • Sheets or cords of malignant cells
  • Cellular atypia & pleomorphism
  • High mitotic rate
  • Necrotic debris in glandular lumina
Colonoscopy with biopsy
Submucous uterine leiomyoma[45][46][47] Menorrhagia - + -
  • Constipation
  • Urinary frequency/incontinence
  • Hydronephrosis
- + Enlarged, irregular, firm, nontender uterus + - - -
  • Trans vaginal US: well defined hypoechoic
  • Saline US: for submucous fibroids/polypoi
Provides information on no: of fibroids, size, vascularization, relationship with endometrial cavity & serosal surface Not required Not required Physical examination with Ultrasound
Uterine cancer[48][49][50][51]
  • Menometorrhagia
  • Intermenstrual bleeding
  • Postcoital bleeding
+ + -
  • Polyuria
  • Dysuria
  • Fatigue
  • Weight loss
+
  • Enlarged uterus
  • Lymphadenpathy
  • Mesenteric nodules (metastases)
+ - - - Thickened endometrial lining >4cm
  • Endometrial thickening
  • Lymph node involvement
  • Pelvic metastases
Not required
  • Endometrial malignant cells
  • Low grade type 1
  • High grade type 2
Histologic diagnosis
Vaginal lymphoma[52][53][54] + + + + Abdominal/pelvic pain - + Palpable mass between rectum & vagina +/- - - - Diffuse mass in external cervical orifice & invading the vagina Diffuse mass in external cervical orifice & invading the vagina Not required CD20 & CD79a positive Immunohistochemistry & biopsy
Vaginal polyp[55][56][57][58] Postmenopausal bleeding + + +
  • Dysperunia
  • Postcoidal bleeding
  • Dysuria
  • Constipation
- + Mass protruding from vagina +/- - - - To exclude uterine hyperplasia/carcinoma To determine the extent N/A Benign tissue/premalignant cells Excisional biopsy
Vaginal adenosis[59][60][61]
  • Intermenstrual bleeding
  • Postmenopausal bleeding
+/- +/- +/- - - - Palpable cysts,nodularity or ulcers - - - - N/A N/A N/A Columnar cells in the ectocervix Biopsy with histopathological examination

References

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