Chronic lymphocytic leukemia physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]Raviteja Guddeti, M.B.B.S. [3]

Overview

Physical examination of patients with chronic lymphocytic leukemia is usually remarkable for skin pallor, palpable cervical lymph nodes, and hepatomegaly.

Physical Examination

General Appearance

• Chronic lymphocytic leukemia patients often appear cachectic

Skin

• Pallor
• Petechiae
• Leukemia cutis (infiltration of neoplastic leukocytes or their precursors into the skin resulting in clinically identifiable cutaneous lesions)

HEENT

• Painless lymph node enlargement (50-90%), usually cervical
• Dacryoadenitis

Abdomen

• Splenomegaly (25 -55%)
• Hepatomegaly (15-25%)

Images

Extremity

• 
  Leukemia. Adapted from Dermatology Atlas.

Trunk

• 
  Leukemia. Adapted from Dermatology Atlas.
• 
  Leukemia. Adapted from Dermatology Atlas.
• 
  Leukemia. Adapted from Dermatology Atlas.