Desmoid tumor diagnostic study of choice

Overview

Diagnostic study of choice for desmoid tumors is biopsy

Biopsy is the most important and conclusive diagnostic procedure for desmoid tumor
After biopsy, electron microscopy is performed to obtain further clarity and confirmation for the diagnosis
Spindle cells of desmoid tumors appear to be myofibroblasts on electron microscopy which represents an abnormal proliferation of myofibroblasts, which normally disappear gradually during the later stages of wound healing
Immunohistochemical stains are done to look for nuclear accumulation of beta-catenin
Regardless of the site, 90% of desmoids show nuclear reactivity (has relatively high specificity)