Hairy cell leukemia differential diagnosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]
Overview
Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.
Differentiating Hairy cell leukemia from other Diseases
- Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.[1][2][3][4][5]
| Differential Diagnosis | Surface Immunoglobulin | CD5 | CD22/FMC7 | CD23 | CD79b | CD103 |
|---|---|---|---|---|---|---|
|
Hairy cell leukaemia |
Strongly positive |
Negative |
Positive |
Negative |
Positive/Negative |
Positive |
|
Chronic lymphocytic leukaemia |
Weakly positive |
Positive |
Negative |
Positive |
Negative |
Positive/Negative |
|
Prolymphocytic leukaemia |
Strongly positive |
Negative |
Positive |
Negative |
Positive |
Negative |
|
Mantle cell lymphoma |
Positive |
Positive |
Strongly positive |
Negative |
Strongly positive |
Negative |
|
Follicular lymphoma |
Strongly positive |
Negative |
Positive |
Negative |
Strongly positive |
Negative |
- Hairy cell leukemia must also be differentiated from other causes of fever, splenomegaly, and fatigue such as:[6][7]
References
- ↑ Troussard X, Cornet E (December 2017). "Hairy cell leukemia 2018: Update on diagnosis, risk-stratification, and treatment". Am. J. Hematol. 92 (12): 1382–1390. doi:10.1002/ajh.24936. PMC 5698705. PMID 29110361.
- ↑ Sainati L, Matutes E, Mulligan S, de Oliveira MP, Rani S, Lampert IA, Catovsky D (July 1990). "A variant form of hairy cell leukemia resistant to alpha-interferon: clinical and phenotypic characteristics of 17 patients". Blood. 76 (1): 157–62. PMID 2364167.
- ↑ Abbrederis K, Michlmayr G, Schmalzl F (1979). "[Prolymphocytic and hairy cell leukemias as special forms of chronic lymphatic leukemia]". Acta Med. Austriaca (in German). 6 (5): 226–8. PMID 299012.
- ↑ Gazitt Y, Polliack A (1987). "Phorbol ester induction of plasmacytoid and hairy cell leukemia features in B-type lymphocytic leukemias: the relation to B-cell differentiation and maturation". Blood Cells. 12 (2): 413–39. PMID 3497682.
- ↑ Hasselbalch H, Lisse I, Berild D, Videbaek A (February 1984). "Spongy lymphoid myelofibrosis as a predictor of hairy cell leukaemia or a variant of hairy cell leukaemia without hairy cells?". Scand J Haematol. 32 (2): 135–44. PMID 6701458.
- ↑ Duggan DJ, Bittner M, Chen Y, Meltzer P, Trent JM (January 1999). "Expression profiling using cDNA microarrays". Nat. Genet. 21 (1 Suppl): 10–4. doi:10.1038/4434. PMID 9915494.
- ↑ Vanhentenrijk V, De Wolf-Peeters C, Wlodarska I (July 2004). "Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature". Blood. 104 (1): 250–5. doi:10.1182/blood-2004-01-0181. PMID 15016649.