Desmoid tumor medical therapy
Desmoid tumor Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Faizan Sheraz, M.D. [3]
Overview
Medical therapy for desmoid tumor includes antiestrogens (ex. tamoxifen), NSAIDs, chemotherapy, or microwave ablation.
Medical Therapy
- Wait and watch or observation is implied as a primary therapeutic option for desmoid tumors with following features:
- Potentially resectable but asymptomatic
- Non-life threatening
- Not causing any significant impairment
- Unresectable tumors
- Resectable but surgery would lead to unacceptable morbidity
- Treatment is recommended for extra-abdominal or abdominal desmoid tumors associated with:
- Symptoms
- Progressively enlarging tumors irrespective of symptoms
- Imminent risk to adjacent structures
- Tumor creating cosmetic concerns
Medical therapy for prolactinoma includes:[1][2]
- Antiestrogens (ex. Tamoxifen)
- NSAIDs
- Chemotherapy
- Microwave ablation shrinking the tumors or slowing down the growth. show shrinkage or stabilization of tumor size or at least improvement in symptoms after a very wide variety of treatments
Drug class | Drug name |
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Chemotherapeutic agents |
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NSAIDs |
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Anti-hormonal agents |
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Tyrosine kinase inhibitors |
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Radiation Therapy
Rarely, radiation therapy is used if medical therapy and surgery fail. Depending on the size and location of the tumor, radiation is delivered either in low doses over the course of 5 to 6 weeks or in a single high dose. Radiation therapy is effective in approximately 30% of cases.
Reference
- ↑ Wilkinson MJ, Fitzgerald JE, Thomas JM, Hayes AJ, Strauss DC (2012). "Surgical resection for non-familial adenomatous polyposis-related intra-abdominal fibromatosis". BJS. 99 (5): 706–13. doi:10.1002/bjs.8703. PMID 22359346.
- ↑ Rammohan A, Wood JJ (2012). "Desmoid tumour of the breast as a manifestation of Gardner's syndrome". Int J Surg Case Rep. 3 (5): 139–42. doi:10.1016/j.ijscr.2012.01.004. PMC 3312056. PMID 22370045.