Adenocarcinoma
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Adenocarcinoma is a form of carcinoma that originates in glandular tissue. To be classified as adenocarcinoma, the cells do not necessarily need to be part of a gland, as long as they have secretory properties. This form of carcinoma can occur in some higher mammals, including humans.[1] The term adenocarcinoma is derived from 'adeno' meaning 'pertaining to a gland' and 'carcinoma', which describes a cancer that has developed in the epithelial cells. It can first present as an adenoma (a glandular tumor that is benign).
Pathophysiology
Examples of tissues where adenocarcinomas may arise:
- Breast cancer
- Colon cancer
- Lung cancer
- Prostate cancer
- Stomach cancer
- Pancreatic cancer (99% of pancreatic cancers are ductal adenocarcinomas [2])
- Cervical cancer
- Vaginal cancer
Gross Pathology
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This cancer presented in a 40-year-old woman complaining of abdominal pain. Endoscopically it was a "very suspicious" ulcer. Biopsy showed diffusely infiltrating signet ring cell adenocarcinoma. These are gross photos of the subtotal gastrectomy specimen. The photo above is a seen face view of the ulcer. The pyloric margin is to the left. The ulcer is on the lesser curvature.
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This is a longitudinal section cut in the plane of the lesser curvature. The pylorus is to the left. Note several prominent nodes of the lesser omentum; these contained metastatic cancer.
Physical Examination
Adenocarcinoma-In The Submandibular Salivary Glands
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Adenocarcinoma-In The Submandibular Salivary Glands
Adapted from Dermatology Atlas -
Adenocarcinoma-In The Submandibular Salivary Glands
Adapted from Dermatology Atlas -
Adenocarcinoma-In The Submandibular Salivary Glands
Adapted from Dermatology Atlas
Differential Diagnosis
| Diseases | Risk factors/Epidemiology | History | Clinical Findings | Gross Pathology | Histopathology | Immunohistochemistry | Lab Findings | Imaging | Metastatic Potential | Gold Standard | Additional Findings |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Head & Neck Cancer | |||||||||||
| Paranasal Sinus Cancer | |||||||||||
| Lung Cancer | |||||||||||
| Breast Cancer | |||||||||||
| Esophageal Cancer | |||||||||||
| Gastric Cancer | |||||||||||
| Pancreatic Cancer | |||||||||||
| Small Bowel Cancer | |||||||||||
| Colorectal Cancer | |||||||||||
| Appendix Cancer | |||||||||||
| Anal Cancer | |||||||||||
| Cervical Cancer | |||||||||||
| Vaginal Cancer | |||||||||||
| Prostate Cancer | |||||||||||
| Bladder Cancer | |||||||||||
| Metastatic Cancer |
References
- ↑ Fauquier, D.A., Gulland, F.M.D.,(Marine Mammal Center), Haulena, M., Spraker, T., ‘’Biliary adenocarcinoma in a stranded Northern elephant seal (‘’Mirounga angustirortsis’‘)’‘, Journal of Wildlife Diseases 39(3):723-726 (2003)