Pineal gland tumor
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Pineal gland tumor Main page |
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Differentiating features among different various Pineal Gland Tumors |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D., Sujit Routray, M.D. [2]
Synonyms and keywords: Pineal gland tumors; Pineal gland cancer; Pineal gland cancers; Pineal gland neoplasm; Pineal gland neoplasms; Neoplasm of the pineal gland; Neoplasms of the pineal gland; Cancer of the pineal gland; Cancers of the pineal gland; Astrocytoma; Meningioma; Pineal gland; Parinaud syndrome; Brain tumor
Overview
The pineal gland is an endocrine gland that is located in the posterior aspect of the cranial fossa in the brain. The pineal gland is responsible for the secretion of melatonin hormone that regulates the in the circadian cycle sleep and wakefulness. The blood supply of the pineal gland is derived from the posterior cerebral artery from its choroidal branches. The internal cerebral vein drains the blood from the epiphysis cerebri. Histologically the gland consists of cells called pinealocytes and supporting cells. Several different tumors can arise from the pineal gland. True pineal cell tumors include pineocytoma, pineoblastoma, and mixed pineal tumors. Tumors that may occur in this region but are not necessarily pineal tumors include germinoma, non-germinoma (eg, teratoma, endodermal sinus tumor, embryonal cell tumor, choriocarcinoma, and mixed tumors), meningioma, astrocytoma, ganglioglioma, and dermoid cysts. Diagnosis of the type of tumor is crucial for treatment. The primary symptom of the tumor would be hydrocephalus. If the pineal gland invades the thalamus, it can cause weakness and loss of sensation in half of the body. Invasion of the hypothalamus would disrupt sleep, impede temperature and water regulation, and cause weight gain. An MRI is important when trying to see the location and size of the tumor. A biopsy is required when trying to determine the type of tumor. Usually, a biopsy is done via a stereotactic or endoscopic procedure. Sometimes biomarkers are used to detect the presence of the tumor, and if these are found in the CSF and blood, then a biopsy might not be needed. Some of these chemicals are beta-human chorionic gonadotropin, carcinoembryonic antigen, and a-fetoprotein.
Classification
Pineal gland tumors are broadly divided into four subcategories. The various types of pineal gland tumors include:[1]
1. Pineal parenchymal tumors: Pineal parenchymal tumors arise directly from the normal functional cells of the pineal gland, pineal parenchymal cells (pineocytes or their precursors), and they are distinct from other pineal gland neoplasms such as astrocytic and germ cell tumors. These tumors are formed after the embryological development of the pineal gland.
2. Pineal germ cell tumors: They are tumors which arise from the embryological abnormalities. They are derived from the germ cells, including sex cells, of the pineal gland during the developmental process of the pineal gland.
3. Astrocytoma of the pineal gland: They arise from the astrocytes, which are a particular kind of star-shaped, glial brain cells around the pineal gland.
4. Pineal metastasis: Pineal metastasis is a cancer that has metastasized to the pineal gland from another location in the body.
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Differentiating pineal gland tumor from Other Diseases
Pineal gland tumormust be differentiated from other diseases that cause seizure, visual disturbance, and constitutional symptoms, such as:
- Oligodendroglioma
- Meningioma
- Astrocytoma
- Pituitary adenoma
- Schwannoma
- primary CNS lymphoma
- Medulloblastoma
- Ependymoma
- Craniopharyngioma
- Hemangioblastoma
- AV malformation
- Brain aneurysm
- Bacterial brain abscess
- Tuberculosis
- Toxoplasmosis
- Hydatid cyst
- CNS cryptococcosis
- CNS aspergillosis
- Brain metastasis
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References
- ↑ Pineal region mass. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/pineal-region-mass. Accessed on November 18, 2015