Seminoma natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Common complications of seminoma include recurrence, lymph node metastasis, distant metastasis, and secondary malignancies. Prognosis is generally good for all stages with greater than 90% cure rate. Seminoma grows slower than non-seminomatous germ cell tumors. The International Germ Cell Cancer Consensus Group divides seminoma into two prognosis groups: good and intermediate. The symptoms of seminoma usually develop in the second to forth decade of life (15-35 years), and start with symptoms such as a painless testicular lump, abnormal semen analysis, possibly an acute onset testicular pain.
Natural History
Seminoma grows slower than non-seminomatous germ cell tumors.[1]
Natural History, Complications, and Prognosis
Natural History
- The symptoms of seminoma usually develop in the second to forth decade of life (15-35 years), and start with symptoms such as a painless testicular lump, abnormal semen analysis, possibly an acute onset testicular pain.
Complications
Common complications of seminoma include:[2]
- Recurrence
- Lymph node metastasis
- Distant metastasis
- Increased risk of seminoma in the remaining testicle
- Increased risk of other cancers (second malignancies)
Prognosis
- Prognosis for stage I is excellent, and the survival rate of patients with seminoma for satgr I is approximately 100%.[3][4]
- Prognosis for stage II is generally good, the 5-year mortality survival rate of patients with satge II of seminoma is approximately 97%.
- Prognosis for stage III is generally good, the 5-year mortality survival rate of patients with satge III of seminoma is approximately 85%
References
- ↑ Cancerous tumours of the testicle. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/testicular-cancer/cancerous-tumours/?region=on. Accessed on February 26, 2016
- ↑ Testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiopaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on March 3, 2016
- ↑ Dong W, Gang W, Liu M, Zhang H (February 2016). "Analysis of the prognosis of patients with testicular seminoma". Oncol Lett. 11 (2): 1361–1366. doi:10.3892/ol.2015.4065. PMC 4734256. PMID 26893743.
- ↑ Honecker, F; Aparicio, J; Berney, D; Beyer, J; Bokemeyer, C; Cathomas, R; Clarke, N; Cohn-Cedermark, G; Daugaard, G; Dieckmann, K -P; Fizazi, K; Fosså, S; Germa-Lluch, J R; Giannatempo, P; Gietema, J A; Gillessen, S; Haugnes, H S; Heidenreich, A; Hemminki, K; Huddart, R; Jewett, M A S; Joly, F; Lauritsen, J; Lorch, A; Necchi, A; Nicolai, N; Oing, C; Oldenburg, J; Ondruš, D; Papachristofilou, A; Powles, T; Sohaib, A; Ståhl, O; Tandstad, T; Toner, G; Horwich, A (2018). "ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up". Annals of Oncology. 29 (8): 1658–1686. doi:10.1093/annonc/mdy217. ISSN 0923-7534.