Sandbox:Sara

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Main effects of UV radiation on normal-appearing human skin

Acute		Chronic
Molecular/cellular	Clinical
DNA photodamage (and its repair)/mutation (C/T, CC/TT) Reactive oxygen species Gene and protein expression Apoptosis Melanogenesis Langerhans cell depletion Nitric oxide release (UVA) Vitamin-D photosynthesis	Erythema Tanning Enhancement of innate immunity Suppression of acquired immunity Reduction of blood pressure via nitric oxide	Skin cancer Photoaging