Extranodal NK-T-cell lymphoma epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]

Epidemiology and Demographics

Mortality rate

• NK cell lymphoma shows a poor prognosis because of rapid local progression and distant metastasis.

Race

• Natural Killer (NK) cell lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.
• Nk cell lymphoma is usually associated with Epstein-Barr virus infection.

Gender

• Extranodal NK/T-cell lymphoma shows male preponderance.

Region

• NK T cell lymphoma, nasal type (NNKTL) consist 3000-10000 out of 100000 cases of non-Hodgkin lymphoma in Asia and South America and less than 1% in Western countries.
• It is estimated the incidence of NNKTL is higher in Asia by 10-folds.

Age

• The median age of onset is approximately 50 years and it is common in elderly.
• Extranodal NK/T-cell lymphoma is a rare disease in children and often it is associated with mosquito-bite hypersensetivity or other EBV-associated disease.