Arnold-Chiari malformation causes

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Arnold-Chiari malformation Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.

Overview

The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.

Causes

  • Common risk factors in the development of Arnold-Chiari malformation include:[1][2]
    • Lumbar-peritoneal shunt
    • Multiple lumbar puncture

Less Common Risk Factors

  • Less common risk factors in the development of Arnold-Chiari malformation include:[3][4][5]



Life-threatening Causes

  • Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of disease name, however complications resulting from untreated disease name is common.
  • Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
  • [Cause] is a life-threatening cause of [disease].

Common Causes

Common causes of [disease name] may include:

  • [Cause1]
  • [Cause2]
  • [Cause3]


OR


  • [Disease name] is caused by an infection with [pathogen name].
  • [Pathogen name] is caused by [pathogen name].

Less Common Causes

Less common causes of [disease name] include:

  • [Cause1]
  • [Cause2]
  • [Cause3]

Genetic Causes

  • Arnold Chiari malformation is caused by a mutation in following genes:
    • PAX1
    • PAX2
    • PAX3
    • PAX6
    • FGF2
    • TBX6
    • HOX gene
    • Noggin gene
    • EFNB1

References

  1. Payner, Troy D.; Prenger, Erin; Berger, Thomas S.; Crone, Kerry R. (1994). "Acquired Chiari Malformations". Neurosurgery. 34 (3): 429–434. doi:10.1227/00006123-199403000-00007. ISSN 0148-396X.
  2. Payner, Troy D.; Prenger, Erin; Berger, Thomas S.; Crone, Kerry R. (1994). "Acquired Chiari Malformations". Neurosurgery. 34 (3): 429–434. doi:10.1227/00006123-199403000-00007. ISSN 0148-396X.
  3. Kuether, Todd A.; Piatt, Joseph H. (1998). "Chiari Malformation Associated with Vitamin D-resistant Rickets: Case Report". Neurosurgery. 42 (5): 1168–1171. doi:10.1097/00006123-199805000-00134. ISSN 0148-396X.
  4. Cinalli, Giuseppe; Spennato, Pietro; Sainte-Rose, Christian; Arnaud, Eric; Aliberti, Ferdinando; Brunelle, Francis; Cianciulli, Emilio; Renier, Dominique (2005). "Chiari malformation in craniosynostosis". Child's Nervous System. 21 (10): 889–901. doi:10.1007/s00381-004-1115-z. ISSN 0256-7040.
  5. Dlouhy, Brian J.; Menezes, Arnold H. (2011). "Osteopetrosis with Chiari I malformation: presentation and surgical management". Journal of Neurosurgery: Pediatrics. 7 (4): 369–374. doi:10.3171/2011.1.PEDS10353. ISSN 1933-0707.


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