Lipoid pneumonia differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
OR
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].
Differentiating lipoid pneumonia from other Diseases
Lipod pneumonia must be differentiated from other diseases that cause Cough with basilar infiltrates, such as bacterial pneumonia, viral pneumonia, congestive heart failure, pulmonary fibrosis, and aspiration pneumonia.[1]
Differentiating exogenous lipoid pneumonia from other diseases on the basis of radiologic features and specimen histologic features.
- Exogenous lipoid pneumonia is usually misdiagnosed as community-acquired pneumonia.
It is considered usually as the initial diagnosis does not lead to an appropriate therapy.
- In patients at risk of aspiration early CT scan is very useful for further diagnosis of lipoid pneumonia.
- Diagnosis is confirmed by detecting intra-alveolar lipid and lipid-laden macrophages.
- specimens could be brought by:
- BAL (Broncho Alveolar Lavage)
- Transthorasic fine-needle aspiration cytology
- Biopsy from lesion
- Sputum examination has questionable reliability because lipid laden macrophages in sputum have been demonstrated in absence of lipoid pneumonia.
- BAL is widely available and choice of specimen taking today.
- Frozen samples must be stained in order to determine type of the oil.
- Since lipid-laden pneumonia is is very sensitive but may not be very specific, the diagnosis of exogenous lipoid pneumonia is based on the triad of:
- History of mineral oil ingestion or vaping
- compatible radiological findings
- presence of intra-alveolar lipids and/or lipid-laden macrophages
| Diseases | Clinical manifestations | Para-clinical findings | Gold standard | Additional findings | |||||||||||
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| Symptoms | Physical examination | ||||||||||||||
| Lab Findings | Imaging | Histopathology | |||||||||||||
| Symptom 1 | Symptom 2 | Symptom 3 | Physical exam 1 | Physical exam 2 | Physical exam 3 | Lab 1 | Lab 2 | Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | ||||
| Differential Diagnosis 1 | |||||||||||||||
| Differential Diagnosis 2 | |||||||||||||||
| Differential Diagnosis 3 | |||||||||||||||
| Diseases | Symptom 1 | Symptom 2 | Symptom 3 | Physical exam 1 | Physical exam 2 | Physical exam 3 | Lab 1 | Lab 2 | Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | Histopathology | Gold standard | Additional findings |
| Differential Diagnosis 4 | |||||||||||||||
| Differential Diagnosis 5 | |||||||||||||||
| Differential Diagnosis 6 | |||||||||||||||