Familial amyloidosis laboratory findings

Familial amyloidosis Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Familial amyloidosis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Familial amyloidosis laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Familial amyloidosis laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Familial amyloidosis laboratory findings
CDC on Familial amyloidosis laboratory findings
Familial amyloidosis laboratory findings in the news
Blogs on Familial amyloidosis laboratory findings
Directions to Hospitals Treating Psoriasis
Risk calculators and risk factors for Familial amyloidosis laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Overview

Laboratory findings in amyloidosis include elevated erythrocyte sedimentation rate, increased BUN level, serum creatinine, protein, casts, or fat cast in urine. Serum troponin, B-type natriuretic peptide, and beta-2-microglobulin are prognostic markers for heart failure.

Laboratory Findings

Cardiac

• Cardiac biomarkers are the most important predictors of outcome in amyloidosis. They provide a quantitative assessment for cardiac damage and wall strain.

• Troponin I or Troponin T
• BNP and NT-proBNP

Hepatic

• Common tests that are abnormal in liver function tests including:

• AST
• ALT
• Total bilirubin
• Alkaline phosphatase
• Albumin

Renal

• Common tests that are abnormal in renal function tests including:

• Serum creatinine
• Urinary protein
• Glomerular filtration rate
• Albumin to creatinine ratio in the urine

Thyroid

• Common tests that are abnormal in thyroidal involvement of amyloidosis include:

• TSH
• Free T4

Bone marrow

• Concurrent multiple myeloma can be found in patients with amyloidosis. In such cases laboratory testing include:

• Serum protein electrophoresis
• Immunoglobulin levels
• Serum free light chains
• Beta-2-microglobulin