Andersen-Tawil syndrome history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]; Raviteja Guddeti, M.B.B.S. [3]

Symptoms

• Seizures - due to oxygen deprivation that occurs during arrhythmia.
• Fainting - fainting or syncope is the most common symptom LQTS.
• A prodrome may occur before losing consciousness, which may consist of lightheadedness, heart palpitations, blurred vision or weakness.
• Sudden death - a fatal arrhythmia that is not quickly intervened on, may cause sudden death.

History and Symptoms

• The majority of patients with [disease name] are asymptomatic.

OR

• The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
• Symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].

History

Patients with Andersen-Tawil Syndrome may have a positive history of:

• Periodic paralysis
• Cardiac symptoms
• Ventricular arrhythmias
• [History finding 3]

Common Symptoms

Common symptoms of Andersen-Tawil Syndrome include:

• Periodic paralysis which are related to hypokalemia and are spontaneous in nature.
• Ventricular arrhythmias.
• Extrasystoles:Premature ventricular contraction
• Arrhythmic syncope.
• Intermittent muscular weakness
• Skeletal developmental abnormalities

Less Common Symptoms

Less common symptoms of Andersen-Tawil Syndrome include:

• SCD(sudden cardiac death) is due to sudden hemodynamic collapse.
• SCA: Spinocerebellar ataxia.
• Generalized seizures, which are often misdiagnosed as primary seizure disorder.
• Learning difficulties.

References

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