Sandbox:Nasrin
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nasrin Nikravangolsefid, MD-MPH [2]
Overview
Acute kidney injury (AKI) or acute renal failure (ARF), is characterized by a rapid reduction of the renal filtration function, which is identified by a rise in serum creatinine concentration.[1]
Historical Perspective
Classification
- Acute kidney injury is classified into three main groups:
1. Prerenal
2. Renal
3. Postrenal
| Type | UOsm | UNa | FeNa | BUN/Cr |
|---|---|---|---|---|
| Prerenal | >500 | <10 | <1% | >20 |
| Renal | <350 | >20 | >2% | <10-15 |
| Postrenal | <350 | >40 | >4% | >20 |
| Type | UOsm | UNa | FeNa | BUN/Cr |
|---|---|---|---|---|
| Prerenal | >500 | <10 | <1% | >20 |
| Renal | <350 | >20 | >2% | <10-15 |
| Postrenal | <350 | >40 | >4% | >20 |
| AKI | |||||||||||||||||||||||||||||||||||
| Prerenal | Renal | Postrenal | |||||||||||||||||||||||||||||||||
| •Nephrotoxicity • contrast dyes • Rhabdomyolysis | • Ischemia • Hypoxia • Hypotension | • Inflammation • Sepsis • Infection | |||||||||||||||||||||||||||||||||
- ↑ Schrier RW, Wang W, Poole B, Mitra A (2004). "Acute renal failure: definitions, diagnosis, pathogenesis, and therapy". J Clin Invest. 114 (1): 5–14. doi:10.1172/JCI22353. PMC 437979. PMID 15232604.