Precocious puberty causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Central Precocious Puberty
If the cause can be traced to the hypothalamus or pituitary, the cause is considered central.
Causes can include:
- Damage to the inhibitory system of the brain (due to infection, trauma, or irradiation)
- hypothalamic hamartoma produces pulsatile gonadotropin-releasing hormone (GnRH)
- Langerhans cell histiocytosis
- McCune-Albright syndrome
- Intracranial neoplasm
- Hydrocephalus
- Angelman syndrome[1]
- Suprasellar arachnoid cysts(SAC)
- Recurrent seizures
Bones can be considered older in individuals with early puberty. Early puberty is marked by growth hormone problems resulting from various brain disorders.
If no cause can be identified, it is considered idiopathic or constitutional.
Peripheral Precocious Puberty
Causes can include:
- Endogenous sources
- Gonadal tumors (such as arrhenoblastoma)
- Adrenal tumors
- Germ cell tumor[2][3]
- Congenital adrenal hyperplasia
- McCune–Albright syndrome
- Exogenous hormones
- Environmental exogenous hormones
- As treatment for another condition
Genetics
central precocious puberty is caused by a mutation in the MKRN3 gene ( makorin ring finger protein 3 ) [+https://ghr.nlm.nih.gov/condition/central-precocious-puberty#genes "Central precocious puberty - Genetics Home Reference - NIH"] Check |url= value (help).
References
- ↑ PMID 15349080 (PMID 15349080)
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- ↑ PMID 15339200 (PMID 15339200)
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