Red eye resident survival guide

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Seyed Arash Javadmoosavi, MD[2]

Overview

Red eye is an essential sign of eye inflammation. Although it is usually benign and can be managed by primary care physician, It is important to distinguish between benign and sight-threatening diagnoses. Its most common cause is conjunctivitis. However, the other common causes are subconjunctival hemorrhage, blepharitis, scleritis, corneal abrasion, glaucoma and foreign body. Red eye can be concomitant photophobia, eye discharge, pain, itiching and visual changes.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

• Acute angle closure glaucoma (AACG)
• Endophthalmitis
• Bacterial keratitis
• Chemical burn
• Traumatic eye injury
• Scleritis
• Corneal ulcer
• Hyper acute conjunctivitis

Common Causes

• Conjunctivitis
• foreign body
• blepharitis
• scleritis
• subconjunctival hemorrhage

Diagnosis

Shown below is an algorithm summarizing the diagnosis of red eye.

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Patients with red eye

Mild or no pain with mild blurring or normal vision

Moderate to severe pain

Hyperemia

Vision loss, Distorted pupil, Corneal involvement

Local

Diffuse

Vesicular rash, Corneal ulcer, Iritis, Acute angle gluacoma, Chemical burn, Traumatic eye injury

Episcleritis

Discharge

Emergency Ophthalmology referral

No

Yes

Subconjunctival hemorrhage

Intermittent

Continuous

Dry eye

Watery or Serous

Mucopurulent to Purulent

Itiching

Clamydial Conjunctivitis

Acute bacterial conjunctivitis

Mild to non

Moderate to severe

Viral Conjunctivitis

Allergic Conjunctivitis

Treatment

The management of the red eye will depend on the underlying cause.

• Life-threatening causes

AACG	Endophthalmitis	Necrotizing Scleritis	Herpetic keratitis	Chemical injury
Lowering of IOP: Acetazolamide 500mg IV or PO + topical Beta blockers, Alpha 2 agonists, Prostaglandin analogue Reduce pain: Topical steroids (prednisolone) Reduce nausea and vomiting: Anti emetics (Metoclopramide)	intravitreal injections of vancomycin and ceftazidime Or combination of vancomycin and amikacin Topical Fluoroquinolones (levofloxacin) Vitrectomy in severe cases	Oral Corticosteroids Or (TNF)-inhibiting anti-inflammatory (adalimumab) or (infliximab)	Ganciclovir 0.15% ophthalmic gel Topical steroid Surgical debridement in severe cases	Emergency treatment Irrigation with isotonic saline or lactate ringer tear substitutes Further treatment Collagenase inhibitors acetylcysteine Topical steroids Ascorbate

• Other causes

Foreign body	Conjunctivits	Blepharitis	Scleritis
Foreign body removal emergently Pain control (cycloplegic eye drops or topical tetracaine) Antibiotics (anti-pseudomonas coverage)	Bacterial Chloramphenicol 0.5% eye drops, Gentamicin 0.3% eye drops, Tetracycline 1% eye ointment Viral Self-limiting just cold compresses to relieve discomfort Allergic Antihistamines (eye drops or orally), Steroid eye drops can be added by cromolyn sodium 4% eye drops and lodoxamide 0.1% eye drops	Bacterial Topical antibiotic, corticosteroid HSV Topical ganciclovir or Oral acyclovir or valacyclovir if nonresolving	First line Topical corticosteroid eyedrops (Prednisolone acetate 1.0%) Oral NSAIDs (Ibuprofen 600 mg) Second line Oral corticosteroids Prescribed when oral NSAID treatment fails

Do's

• Using artificial tears in patients with dry eye.
• Protection against UV rays.
• Observe hygiene protocols.

Don'ts

• Avoid wearing contact lenses.
• Avoid using sharp equipment specially in children.

References

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