Hemosiderosis medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
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Medical Therapy
- There is no treatment for IPH; the mainstay of therapy is supportive care based on the presentation and acute vs. chronic nature of the patient.
- Blood transfusion should be done to correct severe anemia and shock during the acute phase.
- Patients with acute IPH and respiratory failure secondary to alveolar hemorrhage may require invasive ventilation support. It is also recommended to consider immunosuppressive therapy in addition to high dose systemic corticosteroids in these patients.
- Immuno-suppressants such as hydroxychloroquine, azathioprine, cyclophosphamide, and 6-mercaptopurine are sometimes used in combination with steroids for severe cases, or when steroids are contraindicated or not tolerated.
- Other treatment options with unknown efficacies include intravenous immunoglobulin (IVIG), plasmapheresis, liposteroids, and dietary modification (gluten-free diet in those with celiac disease and IPH has been shown to improve symptoms).