Short Stature

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	Short stature
	Classification and external resources
ICD-10	E34.3
ICD-9	783.43
DiseasesDB	18756
MedlinePlus	003271

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ayesha Javid, MBBS [2]

Overview

Short stature is defined as a condition in which the height of an individual is in the 3rd percentile for the mean height of a given age, sex, and population group. According to Ranke (1996), “Short stature is defined as a condition in which the height of an individual is two standard deviations (SD) below the corresponding mean height of a given age, sex and population group.” ^[1]

Historical Perspective

Classification

There are two types of short stature,

Proportionate short stature (PSS)

Proportionate short stature (PSS) is when the person is small, but limbs and trunk height are in proportions.

Disproportionate short stature (DSS)

Whereas in disproportionate short stature (DSS), this proportion is absent, and the individual shows a great difference in his sitting and standing height.

Causes

Physiological causes of Short Stature or Normal Variants of Growth

Familial short stature

Constitutional delay of growth and puberty

Idiopathic short stature

Genetic Causes

Turner's Syndrome
SHOX gene variant
Prader-Willi Syndrome
Noonan syndrome
Silver-Russell syndrome
Skeletal dysplasias/growth plate abnormalities

Endrocrine Causes

Cushing syndrome
Hypothyroidism
Growth hormone deficiency

Epidemiology and Demographics

The American Association of Clinical Endocrinologists defines "short stature" as height more than 2 standard deviations below the mean for age and gender, which corresponds to the shortest 2.3% of individuals.^[2]

References

↑ "StatPearls". 2020. PMID 32310491 Check |pmid= value (help).
↑ "FDA Approves Humatrope for Short Stature". U.S. Food and Drug Administration. 2003-07-25. Retrieved 2009-01-13.^{[dead link]}

Template:WH Template:WikiDoc Sources

[pmid32310491-1] "StatPearls". 2020. PMID 32310491 Check |pmid= value (help).

[urlFDA_Approves_Humatrope_for_Short_Stature-2] "FDA Approves Humatrope for Short Stature". U.S. Food and Drug Administration. 2003-07-25. Retrieved 2009-01-13.^{[dead link]}

[1]

[2]