Alopecia pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jose
Overview
Since alopecia ha many different causes, the pathophysiologic mechanism for its development varies according to the cause.
Pathophysiology
Alopecia Areata
- The exact pathogenesis of alopecia areata is not fully understood.
- It has been theorized that T-cell-mediated autoimmunity must be involved in its development.
- The hair follicle typically has low levels of major histocompatibility complex expression, which provides protection from the immune system. It is believed that in alopecia Areata that protection is lost, resulting in a CD8+ T lymphocyte attack to the bulb of the hair, generating an inflammatory infiltrate in the [[peribulbar[[ region of the hair follicle.[1][2]
- Genes involved in the pathogenesis of alopecia areata include MCHR2 and MCHR2-AS1 which are related to the MHC pathway (melanin concentrating hormone).[3]
- There is an association of alopecia Areata with other autoimmune diseases such as vitiligo, autoimmune thyroid disease, celiac disease, systemic erythematous, chronic atrophic gastritis which further reinforces its relationship with autoimmunity.[4]
=Telogen effluvium
- In telogen effluvium, the hair loss may influenced by hormones or stress, or other unknown factors. [5] The dermatophyte infection is responsible for hair loss in tinea capitis. In anagen effluvium, the shedding of hair is under the effect of chemotherapeutic agents. In alopecia mucinosa, the infiltration of the scalp with abnormal lymphocytes is the cause. [6]
Pathogenesis
Pathogenesis is the mechanism by which a certain factor causes disease (pathos = disease, genesis = development). The term can also be used to describe the development of the disease, whether it is acute, chronic, or recurrent. It can also be used to describe whether the disease causes inflammation, malignancy, necrosis etc.
Template Sentences
IF the pathogenesis of the disease is unclear:
- It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
IF the disease is infectious…
- …and the route of transmission is known:
- [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
- Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
IF the disease has a known genetic component:
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
IF certain pathology findings are characteristic of the disease:
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Genetics
- Some diseases are genetic, and have particular inheritance patterns, and express different phenotypes.
- The effect that genetics may have on the pathophysiology of a disease can be described in this section.
Template sentences
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
Associated Conditions
- Conditions associated with the disease can be detailed in this section.
Template sentences
- The most important conditions/diseases associated with [disease name] include:
- Condition 1: A brief explanation of the condition and its association with the disease
- Condition 2: A brief explanation of the condition and its association with the disease
For an example of an associated conditions sub-section of pathophysiology, click here.
Histopathology
In androgenetic alopecia, there are miniaturized hair follicles with an increase in the telogen-to-anagen ratio without inflammatory reaction. In anagen effluvium, there is a decrease in anagen hair without any inflammatory response. Finally, in alopecia mucinosa, there is an infiltrate of the epidermis, dermis, and peribulbar lymphocytic infiltrate mainly anaplastic cells. In patients with alopecia areata, there is a peribulbar lymphocytic infiltrate with a decrease in the ratio of anagen to telogen hair. Telogen effluvium is characterized by an increase in the number of catagen hair. In tinea capitis, there is evidence of fungal infection as under a microscope along with a neutrophilic infiltrate.
References
- ↑ Paus R, Ito N, Takigawa M, Ito T (2003). "The hair follicle and immune privilege". J Investig Dermatol Symp Proc. 8 (2): 188–94. doi:10.1046/j.1087-0024.2003.00807.x. PMID 14582671.
- ↑ Paus R, Bertolini M (2013). "The role of hair follicle immune privilege collapse in alopecia areata: status and perspectives". J Investig Dermatol Symp Proc. 16 (1): S25–7. doi:10.1038/jidsymp.2013.7. PMID 24326544.
- ↑ Fischer J, Degenhardt F, Hofmann A, Redler S, Basmanav FB, Heilmann-Heimbach S; et al. (2017). "Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2". Exp Dermatol. 26 (6): 536–541. doi:10.1111/exd.13123. PMID 27306922.
- ↑ Trüeb RM, Dias MFRG (2018). "Alopecia Areata: a Comprehensive Review of Pathogenesis and Management". Clin Rev Allergy Immunol. 54 (1): 68–87. doi:10.1007/s12016-017-8620-9. PMID 28717940.
- ↑ Yu L, Lu Z (2018) Linear alopecia areata. JAAD Case Rep 4 (10):1072-1073. DOI:10.1016/j.jdcr.2018.08.015 PMID: 30511001
- ↑ Davey L, Clarke V, Jenkinson E (2019). "Living with alopecia areata: an online qualitative survey study". Br J Dermatol. 180 (6): 1377–1389. doi:10.1111/bjd.17463. PMID 30501016.