Urticaria causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anahita Deylamsalehi, M.D.[2]
Overview
Disease name] may be caused by [cause1], [cause2], or [cause3].
Causes
Common Causes
Common causes of urticaria may include:[1]
- Idiopathic
- Unknown etiology
- Immunological:
- Autoimmune IgG autoantibodies to IgE Receptor or IgE on mast cells is the responsible mechanism.
- IgE/contact urticaria: Contact with allergen cross-links specific IgE (SIgE) on mast cells.
- Immune complex:
- Mostly due to infections.
- Urticarial vasculitis
- Non-immunological:
- Physical urticaria: Physical factors trigger histamine release from mast cells
- Drug treatment:
- Sensitivity to Cyclo-oxygenase (COX)-inhibitors
- Direct mast cell histamine release
- Dietary pseudo-allergens: Sensitivity to natural salicylates, colourings, preservatives.
- Medical conditions:
- Urticaria pigmentosa: Increased mast cell load
- Periodic syndrome (CAPS): Due to a mutation in CIAS1 gene.
References
- ↑ Deacock SJ (2008). "An approach to the patient with urticaria". Clin Exp Immunol. 153 (2): 151–61. doi:10.1111/j.1365-2249.2008.03693.x. PMC 2492902. PMID 18713139.