Epileptic Heart
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
Chronic epileptic episodes and the subsequent catecholamine surges and hypoxia events may affect the heart and coronary vessels and result in the dysfunction of the heart, this condition has known as the epileptic heart. This concept first described by Dr. Richard L. Verrier and his colleagues in 2020.
Historical Perspective
- The Absence of cardiac activity during epilepsy, first described by Dr. A.E.Russell, an English physician, in 1906.[1]
- The epileptic heart was first discribed by Dr. Richard L. Verrier and his colleagues, in 2020.[2]
Pathophysiology
The exact mechanisms involved in the epileptic heart is still should be elucidated. However, the algorithm below provides beneficial information on the development of heart disease in the context of epilepsy.[3]
| Epilepsy | |||||||||||||||||||||||||||||||||||||||
| Cardiac effects | |||||||||||||||||||||||||||||||||||||||
| Repeated hypoxia and subsequent myocardial ischemia | Cathecholamines-induced cardiotoxicity | ||||||||||||||||||||||||||||||||||||||
| Accelerated atherosclerosis | Myocardial stunning | Vacuolization of myocytes and fibrosis | |||||||||||||||||||||||||||||||||||||
References
- ↑ Russell, A.E. (1906). "CESSATION OF THE PULSE DURING THE ONSET OF EPILEPTIC FITS,". The Lancet. 168 (4325): 152–154. doi:10.1016/S0140-6736(01)30477-4. ISSN 0140-6736.
- ↑ Verrier, Richard L.; Pang, Trudy D.; Nearing, Bruce D.; Schachter, Steven C. (2020). "The Epileptic Heart: Concept and clinical evidence". Epilepsy & Behavior. 105: 106946. doi:10.1016/j.yebeh.2020.106946. ISSN 1525-5050.
- ↑ Verrier, Richard L.; Schachter, Steven C. (2018). "Is heart disease in chronic epilepsy a consequence of seizures or a fellow traveler?". Epilepsy & Behavior. 86: 211–213. doi:10.1016/j.yebeh.2018.06.027. ISSN 1525-5050.