Sudden cardiac death pathophysiology

Sudden cardiac death Microchapters
Home
Patient Information
Sudden Cardiac versus Non-Cardiac Death
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Definitions and Diagnosis
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Urgent Treatment
Post Arrest Care and Prevention
Ethical Issues
Sudden cardiac death pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Sudden cardiac death pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Sudden cardiac death pathophysiology
CDC on Sudden cardiac death pathophysiology
Sudden cardiac death pathophysiology in the news
Blogs on Sudden cardiac death pathophysiology
Directions to Hospitals Treating Sudden cardiac death
Risk calculators and risk factors for Sudden cardiac death pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Zand, M.D.[2]

Overview

The pathogenesis of cardiac arrest is characterized by the myocardial inflammatory process in the setting of atherosclerosis, structural heart disease, genetic disorders, and environmental factors. The SCN5A, KCNH2, KCNQ1, RYR2, MYBPC3, PKP2, DSP genes mutation are associated with the development of inherited causes of cardiac arrest and sudden cardiac death.

Pathophysiology

• The pathogenesis of cardiac arrest is characterized by the myocardial inflammatory process in the setting of atherosclerosis, structural heart disease, genetic disorders, and environmental factors.
• The SCN5A, KCNH2, KCNQ1, RYR2, MYBPC3, PKP2, DSP genes mutation are associated with the development of inherited causes of cardiac arrest and sudden cardiac death.

|

Structural and functional causes of sudden cardiac death Coronary artery disease Cardiomyopathy Valvular heart disease Congenital heart disease Primary electrical abnormality Channelopathy

Trigger Myocardial infarction Myocardial ischemia/reperfusion Emotional, physical stress Hemodynamic decompensation Electrolyte imbalance Hypoxemia,acidosis Neurophysiological interactions Drugs

Arrhythmia mechanism Re-entry Automaticity Triggered activity Conduction block

Fatal arrhythmia Monomorphic ventricular tachycardia Polymorphic ventricular tachycardia Ventricular fibrillation Profound bradycardia Asystole Pulseless electrical activity