Pulmonary hypertension historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]: Associate Editor(s)-in-Chief: Anthony Gallo, B.S. [2]
Overview
Pulmonary hypertension was first described by Ernst von Romberg, a German physician, in 1891.
Historical Perspective
- Pulmonary hypertension was first described by Ernst von Romberg, a German physician, in 1891.
- Dresdale investigated the effects of tolzoline in a woman with pulmonary arterial hypertension causing a sudden reduction in pulmonary vascular resistance;
- In the late 1960s there was an epidemic of pulmonary arterial hypertension induced by aminorex which sparked interest on the disease;
- Pulmonary hypertension was first classified into primary and secondary in 1973 during the World Health Organization (WHO) meeting on PH in Geneva, Switzerland;
- Bosentan was approved to treat pulmonary hypertension in 2001, and sildenafil was approved in 2005.[1]
References
- ↑ Barst RJ (2008). "Pulmonary hypertension: past, present and future". Ann Thorac Med. 3 (1): 1–4. doi:10.4103/1817-1737.37832. PMC 2700428. PMID 19561874.