Caplans syndrome diagnostic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Chest X ray and pulmonary function test are very helpful to diagnose Caplan Syndrome. Biopsy of the lung nodules are confirmatory test.

Diagnostic Study of Choice

Study of choice

Biopsy of the lung nodules is the golden diagnostic test for the diagnosis of Caplan Syndrome.but Caplan Syndrome can be initially diagnosed based on chest x ray and pulmonary function test.

Name of Diagnostic Criteria

Caplan Syndrome may be diagnosed at any time if one or more of the following criteria are met:

• Multiple, round, well defined nodules seen in Chest x ray which are usually 0.5-2 cm in diameter, cavitating resembling tuberculosis.CT guided thoracic punch biopsy of the lung nodules show typical features of rheumatoid nodules surrounded by palisade macrophages.
• Combination of obstructive and restrictive features in lung function test and decreased diffusing capacity of carbon monoxide.
• Serum study can show the presence of Rheumatoid factor, antinuclear antibodies or non organ specific antibodies.