Autoimmune lymphoproliferative syndrome other imaging findings
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Differentiating Autoimmune lymphoproliferative syndrome from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Fluorodeoxyglucose positron emission tomography (FDG-PET) may be helpful in the diagnosis of Autoimmune lymphoproliferative syndrome(ALPS) by distinguishing benign lymphadenopathy from malignant lymphadenopathy.
Other Imaging Findings
uptake of FDG in the various subgroups of ALPS without lymphoma appears visually and quantitatively to overlap with findings in ALPS patients with HL and NHL. Even intense FDG uptake does not by itself merit biopsy or signify lymphoma in ALPS, and hence routine FDG imaging of these patients is not indicated. Despite this, when lymphoma is suspected on clinical grounds, FDG imaging can be used to guide biopsy choice of an affected lymph node based on maximum FDG avidity. Furthermore, in those patients with active lymphoma, FDG can still be utilized to assess for tumor response and relapse, as it is done in other lymphomas.