Angiodysplasia overview
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Overview
In medicine (gastroenterology), angiodysplasia is a small, acquired vascular malformation of the gut. It is a common cause of otherwise unexplained gastrointestinal bleeding and anemia, especially after sixth decade of life. Lesions are often multiple, and frequently involve the cecum or ascending colon, although they can occur at other places. Treatment may be with endoscopic interventions, medication, or occasionally surgery.
Historical Perspective
The first case of angiodysplasia was described in a letter to the London Medical Gazette by Phillips as a vascular abnormality causing bleeding from the large bowel in 1839. However, the term "Angiodysplasia" was coined by Galdabini in 1974. Due to the unknown etiology of these lesions, multiple terms have been used, like arteriovenous malformation, telangiectasia, angioma, and hemangioma.[1]
Classification
One system of classification is based on location, size, and number of angiodysplasias. [2]
| Location | Size | Number of lesions |
|---|---|---|
| Gastric | Minute (<2 mm in diameter) | Unique (n = 1) |
| Duodenal | Intermediate (2 to 5 mm) | Multiple (n = 2 to 10) |
| Jejunal | Large (>5 mm) | Diffuse (n > 10) |
| Colonic | ||
| For example, "D-S2-N3" signifies multiple angiodysplasias of intermediate size in the duodenum. | ||
Another system of classification uses endoscopic techniques to classify angiodysplasia depending on size, bleeding and surrounding venous dilatation.
Pathophysiology
Causes
Differentiating Angiodysplasia overview from Other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
Natural History
Complications
Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Prevention
References
- ↑ Athanasoulis, C. A.; Galdabini, J. J.; Waltman, A. C.; Novelline, R. A.; Greenfield, A. J.; Ezpeleta, M. L. (1978). "Angiodysplasia of the colon: A cause of rectal bleeding". Cardiovascular Radiology. 1 (1): 3–13. doi:10.1007/BF02551967. ISSN 0342-7196.
- ↑ Schmit A, Van Gossum A (1998). "Proposal for an endoscopic classification of digestive angiodysplasias for therapeutic trials. The European Club of Enteroscopy". Gastrointest Endosc. 48 (6): 659. doi:10.1016/s0016-5107(98)70080-x. PMID 9852467.