Pyonephrosis pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Harsh Vardhan Chawla, M.B.B.S.[2]

Overview

Pathophysiology of Pyonephrosis

Pyonephrosis can be seen as a complication of acute pyelonephritis, usually seen with complete or incomplete obstruction of tubules. Obstruction of ureter and renal pelvis causes dilatation of tubular system which in turn leads to hydronephrosis. The dilatation of the tubular system serves as a nidus for infection because the pathogens multiply easily in obstructed and dilated tubules leading to suppurative inflammation.

Pathophysiology

• Pyonephrosis can be seen as a complication of acute pyelonephritis, usually seen with complete or incomplete obstruction of tubules.
• Obstruction of ureter and renal pelvis causes dilatation of tubular system which in turn leads to hydronephrosis.
• The dilatation of the tubular system serves as a nidus for infection because the pathogens multiply easily in obstructed and dilated tubules leading to suppurative inflammation.
• The exudates fill the tubules, renal pelvis, calyces, and ureter with pus that is difficult to drain.
• The accumulation of pus in the tubules eventually leads to structural and functional loss of the renal parenchyma which can cause a complete or incomplete loss of function initially.
• The combination of obstruction with the infections may rapidly progress to sepsis.
• Therefore, it becomes critical to promptly diagnose and treat the condition to prevent renal loss of function and bloodstream infection leading to sepsis.