Diabetic nephropathy secondary prevention
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Once diabetic nephropathy develops, secondary prevention to halt the progression of the disease is aimed at strict control of blood pressure, blood glucose levels, as well as lipids.
Secondary Prevention
Once diabetic nephropathy develops, secondary prevention to halt the progression of the disease is aimed at:
- Renin-angiotensin-aldosterone system RAAS with ACE inhibitors or angiotensin II receptor antagonists, the Cochrane Collaboration reported a reduction in renal outcomes. This includes a regression to normoalbuminuria (in analysis 1.6 regression was found in 201/995 [20%]; risk ratio 3.06).
- Per the Cochrane, this benefit is not affected by moderately increased albuminuria (30 to 300 mg/day; A2 or microalbuminuria) or severely increased albuminuria (>300 mg/day; A3 or microalbuminuria)