Cancer of unknown primary origin

Cancer of unknown primary origin

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Cancer of unknown primary (CUP) origin is the diagnosis when metastatic cancer is found but the place where the cancer began (the primary site) cannot be determined. About 2 to 4 percent of all cancer patients have a cancer whose primary site is never identified.

Treatment for CUP depends on many factors, including where the metastatic cancer is found, what the cancer cells look like under a microscope, and the patient’s age and general health.

Recent advances in diagnostic techniques have improved doctors’ ability to eventually find the primary site, even when the original diagnosis is CUP.