CYP4F2

Cytochrome P450, family 4, subfamily F, polypeptide 2
Identifiers
Symbols	CYP4F2 ; CPF2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 88644
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

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Evidence Based Medicine
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Clinical Trials
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Guidelines / Policies / Govt
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News
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Commentary
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Definitions
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Continuing Medical Education (CME)
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Overview

Cytochrome P450, family 4, subfamily F, polypeptide 2, also known as CYP4F2, is a human gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.

Further reading

• Simpson AE (1997). "The cytochrome P450 4 (CYP4) family". Gen. Pharmacol. 28 (3): 351–9. PMID 9068972.
• Kikuta Y, Kusunose E, Kondo T; et al. (1994). "Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver". FEBS Lett. 348 (1): 70–4. PMID 8026587.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen L, Hardwick JP (1993). "Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors". Arch. Biochem. Biophys. 300 (1): 18–23. PMID 8424651.
• Powell PK, Wolf I, Jin R, Lasker JM (1998). "Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11". J. Pharmacol. Exp. Ther. 285 (3): 1327–36. PMID 9618440.CS1 maint: Multiple names: authors list (link)
• Kikuta Y, Miyauchi Y, Kusunose E, Kusunose M (1999). "Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene". DNA Cell Biol. 18 (9): 723–30. doi:10.1089/104454999315006. PMID 10492403.CS1 maint: Multiple names: authors list (link)
• Lasker JM, Chen WB, Wolf I; et al. (2000). "Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11". J. Biol. Chem. 275 (6): 4118–26. PMID 10660572.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang X, Chen L, Hardwick JP (2000). "Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells". Arch. Biochem. Biophys. 378 (2): 364–76. doi:10.1006/abbi.2000.1836. PMID 10860554.CS1 maint: Multiple names: authors list (link)
• Zhang X, Hardwick JP (2001). "Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells". Biochem. Biophys. Res. Commun. 279 (3): 864–71. doi:10.1006/bbrc.2000.4020. PMID 11162441.
• Peng X, Pan X, Kenga M (2002). "[Isolation and sequencing of a novel form of cytochrome p-450 4F family from human liver]". Zhonghua Yi Xue Za Zhi. 79 (11): 860–2. PMID 11715494.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagata T, Takahashi Y, Ishii Y; et al. (2004). "Profiling of genes differentially expressed between fetal liver and postnatal liver using high-density oligonucleotide DNA array". Int. J. Mol. Med. 11 (6): 713–21. PMID 12736711.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsu MH, Savas U, Griffin KJ, Johnson EF (2007). "Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin". J. Biol. Chem. 282 (8): 5225–36. doi:10.1074/jbc.M608176200. PMID 17142457.CS1 maint: Multiple names: authors list (link)
• Sontag TJ, Parker RS (2007). "Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase". J. Lipid Res. 48 (5): 1090–8. doi:10.1194/jlr.M600514-JLR200. PMID 17284776.
• Stec DE, Roman RJ, Flasch A, Rieder MJ (2007). "Functional polymorphism in human CYP4F2 decreases 20-HETE production". Physiol. Genomics. 30 (1): 74–81. doi:10.1152/physiolgenomics.00003.2007. PMID 17341693.CS1 maint: Multiple names: authors list (link)