Proamanullin

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Proamanullin

File:Proamanullin structure.png
File:Proamanullin 3d chemical structure.png
Names
Other names 2-L-Proline-3-isoleucine-alpha-amanitin
Identifiers
CAS Number	54532-46-6
3D model (JSmol)	Interactive image
ECHA InfoCard
PubChem CID	171350
SMILES O=C(NCC(N[C@@](C(NCC(N[C@@H](C3)C(N[C@@H](CC(N)=O)C(N5[C@H]4CCC5)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)[C@H](CC1=C(S3=O)NC2=C1C=CC(O)=C2)NC([C@@]([C@@H](C)CC)([H])N[C@@]4=O)=O
Properties
Chemical formula	C39H54N10O11S
Molar mass	870.97 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Promanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms.

Toxicology

Like other amatoxins, proamanullin is an inhibitor of RNA polymerase II. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).

See also

• Mushroom poisoning

External links

• Amatoxins REVISED