Nedocromil

Nedocromil

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Clinical data
Routes of administration	Inhalation and eye drops
ATC code	R01AC07 (WHO) R03BC03 (WHO), S01GX04 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Protein binding	89%
Metabolism	not metabolized
Elimination half-life	~3.3 hours
Excretion	excreted unchanged
Identifiers
IUPAC name 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro- 4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
CAS Number	69049-73-6
PubChem CID	50294
DrugBank	APRD01137
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C19H17NO7
Molar mass	371.341 g/mol

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Overview

Nedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade.

Nedocromil is classified as a cromone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes.