Mitral regurgitation differential diagnosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Varun Kumar, M.B.B.S.; Lakshmi Gopalakrishnan, M.B.B.S.
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Common Causes of Mitral Regurgitation
Chronic Mitral Regurgitation
- Developed World: Mitral valve prolapse (MVP), which caused by myxomatous degeneration.[1]
- Developing World: Rheumatic heart disease
- Ischemic heart disease causes mitral regurgitation by the combination of ischemic dysfunction of the papillary muscles, the abnormal motion of the underlying wall, and the dilatation of the left ventricle that is present in ischemic heart disease, with the subsequent displacement of the papillary muscles and the dilatation of the mitral valve annulus.
- Marfan's syndrome [2]
- Secondary mitral regurgitation due to the dilatation of the left ventricle, caused by stretching of the mitral valve annulus and displacement of the papillary muscles. This dilatation of the left ventricle can be due to any cause of dilated cardiomyopathy, including aortic insufficiency, nonischemic dilated cardiomyopathy and Noncompaction Cardiomyopathy. It is also called functional mitral regurgitation, because the papillary muscles, chordae, and valve leaflets are usually normal.[3]
Acute Mitral Regurgitation
- Acute bacterial endocarditis. The predominant organism is S. aureus, but varies depending upon the patient.[2]
- Papillary muscle rupture or dysfunction,[2] associated with ST elevation myocardial infarction
Full Differential Diagnosis of Causes of Mitral Regurgitaion
Listed alphabetically:
- Amyloid[4]
- Cardiomyopathy
- Coronary Heart Disease
- Congenital mitral regurgitation
- Ehlers-Danlos Syndrome
- Heart Failure
- Hypertrophic obstructive cardiomyopathy
- Infective endocarditis
- Left ventricular dilation
- Marfan Syndrome
- Mitral annular calcification
- Mitral valve prolapse
- Myocardial Infarction
- Myocardial ischemia
- Myxomatous degeneration
- Osteogenesis imperfecta
- Prosthetic valve dysfunction
- Rheumatic Heart Disease
- Syphilis if left untreated
- Systemic Lupus Erythematosus
- Trauma
Complete Differential Diagnosis of the Causes of Mitral Regurgitation
(By organ system)
| Cardiovascular | | Cardiomyopathy | Coronary Heart Disease |Congenital mitral regurgitation | Dilation of Mitral annulus due to Heart Failure | Hypertrophic obstructive cardiomyopathy | Infective endocarditis | Left ventricular dilation | Mitral annular calcification | Mitral valve prolapse | Myocardial Infarction | Myocardial ischemia | Myxomatous degeneration | Prosthetic valve dysfunction |
| Chemical / poisoning | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | Ehlers-Danlos Syndrome | Marfan Syndrome | Osteogenesis imperfecta |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | Endocarditis most often due to Staphylococcus aureus [2] | Syphilis |
| Musculoskeletal / Ortho | Infective endocarditis |
| Neurologic | No underlying causes |
| Nutritional / Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Opthalmologic | No underlying causes |
| Overdose / Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal / Electrolyte | No underlying causes |
| Rheum / Immune / Allergy | Amyloid | Ehlers-Danlos Syndrome Rheumatic Heart Disease | Systemic Lupus Erythematosus |
| Sexual | No underlying causes |
| Trauma | Trauma and motor vehicle accident |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
References
- ↑ Kulick, Daniel. "Mitral Valve Prolapse (MVP)". MedicineNet.com. MedicineNet, Inc. Retrieved 2010-01-18.
- ↑ 2.0 2.1 2.2 2.3 Elizabeth D Agabegi; Agabegi, Steven S. (2008). Step-Up to Medicine (Step-Up Series). Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-7153-6. Chapter 1: Diseases of the Cardiovascular system > Section: Valvular Heart Disease
- ↑ Functional mitral regurgitation By William H Gaasch, MD. Retrieved on Jul 8, 2010
- ↑ British Medical Journal case reports; doi:10.1136/bcr.08.2008.0821