Pericarditis causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pericarditis can present as a disorder primarily involving the pericardium (e.g viral etiologies), as manifestation of a systemic illness (e.g. autoimmune illnesses), or as a manifestation of a disorder involving an adjacent anatomic structure (e.g. cancer).
Common Causes of Pericarditis [1]
- (35%) Neoplastic
- (23%) Autoimmune
- (21%) Viral - adenovirus, enterovirus, cytomegalovirus, influenza virus, hepatitis B virus, and herpes simplex virus, etc
- ( 6%) Bacterial (other than tuberculosis)
- ( 6%) Uremia
- ( 4%) Tuberculosis
- ( 4%) Idiopathic
- (remaining) trauma, drugs, post-AMI, myocarditis, dissecting aortic aneurysm, radiation
Complete Differential Diagnosis of the Causes of Pericarditis
(By organ system)
| Cardiovascular | Post-MI (Dresslers) |
| Chemical / poisoning | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Usually associated with small effusions. Common culprits include hydralazine, procainamide, DOH, isoniazid, phenylbutazone, dantrolene, doxorubicin, methylsergide, penicillin. |
| Ear Nose Throat | No underlying causes |
| Endocrine | Usually in conjunction with clinically severe hypothyroidism. Most early case reports associated with myxedema and patients also had ascites, pleural effusions and uveal edema. Often resolves with thyroid replacement therapy. |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | *Viral: Coxsackie B Virus, Echovirus, Adenovirus (less commonly: Mumps, Influenza, varicella, Hepatitis B and CMV-especially in HIV patients.) Usually associated with a viral prodrome and acute pericarditis.
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| Musculoskeletal / Ortho | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional / Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | Predominantly lung, breast, leukemia, lymphomas (Hodgkins and non-Hodgkins). Less commonly GI malignancies, ovarian cancer, sarcomas and melanomas, metastic, hematogenous, carcinoma, carcinoid, Sipple syndrome, mesothelioma, fibroma, lipoma . Also Kaposis sarcoma in HIV positive patients. |
| Opthalmologic | No underlying causes |
| Overdose / Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal / Electrolyte | Uremic pericarditis is seen in up to 20% of uremic patients requiring chronic hemodialysis. The mechanism is unknown. Most commonly there is a small effusion associated with pain and a pericardial friction rub, but there can be a large effusion and present with tamponade |
| Rheum / Immune / Allergy | *Systemic Lupus Erythematosus or SLE: Pericarditis usually occurs in the setting of disease flares (systemic symptoms, high erythrocyte sedimentation rate (ESR) , +ANA, +dsDNA, pleural effusions). Occurs in 20-40% of patients with SLE during the course of the disease. Usually the fluid is serous or grossly bloody. Analysis of the fluid usually reveals a high protein and low glucose content. Typically WBC count is less than 10K, and is made up of primarily polymorphonuclear cells (PMNs).
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| Sexual | No underlying causes |
| Trauma | After chest trauma, throacic surgery, PCM insertion, Valvuloplasty. Also from esophageal rupture, pancreatic-pericardial fistula (check amylase), penetrating chest injury, esophogeal perforation, gastric perforation, during catheterization (pacemaker insertion, cathether ablation for arrhythmias, diagnostic, PCI with coronary dissection). |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
post-pericardiotomy, radiation, dissecting aortic aneurysm, chylopericardium (from thoracic duct obstruction secondary to tumor, surgical procedure, trauma, TB, congenital). Also, sarcoidosis, amyloidosis, IBD, Whipple's, temporal arteritis and Behcet syndrome).
Differential Diagnosis of Causes of Acute Pericarditis
In alphabetical order:
- Actinomycosis
- Acute idiopathic pericarditis
- Acute rheumatic fever
- Adenovirus
- Addison's crisis
- Amyloidosis
- Amebiasis
- Ankylosing Spondylitis
- Aortic dissection
- Behcet's Disease
- Borrelia
- Breast cancer
- Chylopericardium
- Coxsackie A
- Coxsackie B
- Cytomegalovirus
- Dermatomyositis
- Dermatosclerosis
- Dressler's Syndrome
- EBV
- ECHO virus
- Echinococcosis
- Familial Mediterranian Fever
- Francisella
- HIV
- Infectious mononucleosis
- Inflammatory Bowel Disease
- Influenza virus
- Legionella
- Leukemia
- Lung cancer
- Lymphoma
- Meningococci
- Mixed Connective Tissue Disease
- Mumps virus
- Mycoplasma infection
- Neisseria gonorrhoeae
- Perforated esophagus
- Pneumococci
- Polyarteritis Nodosa
- Polymyositis
- Postpericardiotomy syndrome
- Reiter's Syndrome
- Radiation therapy
- Renal Failure
- Rheumatoid Arthritis
- Rickettsia
- Sarcoidosis
- Scleroderma
- Serum sickness
- Staphylococci
- Streptococci
- Systemic Lupus Erythematosus
- Thorax trauma
- Treponema pallidum
- Toxoplasmosis
- Tuberculosis
- Uremia
- Varicella virus
- Wegener's granulomatosis
- Whipple's Disease
Differential Diagnosis of Causes of Chronic Pericarditis
In alphabetical order:
- Amebiasis
- Bacterial infections
- Cholesterol pericarditis
- Chylopericardium
- Coccidioidomycosis
- Collagen Vascular Disease
- Coxsackie B
- Echinococcosis
- Histoplasmosis
- Neoplastic pericarditis
- Tuberculosis
- Uremic pericarditis
References
- ↑ Maisch B, Ristic AD (2002). "The classification of pericardial disease in the age of modern medicine". Curr Cardiol Rep. 4 (1): 13–21. doi:10.1007/s11886-002-0121-6. PMID 11743917.