Mitral regurgitation differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Varun Kumar, M.B.B.S.; Lakshmi Gopalakrishnan, M.B.B.S.

Full Differential Diagnosis of Causes of Mitral Regurgitaion

Listed alphabetically:

• Amyloid
• Cardiomyopathy
• Coronary Heart Disease
• Congenital mitral regurgitation
• Ehlers-Danlos Syndrome
• Heart Failure
• Hypertrophic obstructive cardiomyopathy
• Infective endocarditis
• Left ventricular dilation
• Marfan Syndrome
• Mitral annular calcification
• Mitral valve prolapse
• Myocardial Infarction
• Myocardial ischemia
• Myxomatous degeneration
• Osteogenesis imperfecta
• Prosthetic valve dysfunction
• Rheumatic Heart Disease
• Syphilis if left untreated
• Systemic Lupus Erythematosus
• Trauma

Complete Differential Diagnosis of the Causes of Mitral Regurgitation

(By organ system)

Cardiovascular	| Cardiomyopathy | Coronary Heart Disease |Congenital mitral regurgitation | Dilation of Mitral annulus due to Heart Failure | Hypertrophic obstructive cardiomyopathy | Infective endocarditis | Left ventricular dilation | Mitral annular calcification | Mitral valve prolapse | Myocardial Infarction | Myocardial ischemia | Myxomatous degeneration | Prosthetic valve dysfunction
Chemical / poisoning	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Ehlers-Danlos Syndrome | Marfan Syndrome | Osteogenesis imperfecta
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	Endocarditis most often due to Staphylococcus aureus | Syphilis
Musculoskeletal / Ortho	Infective endocarditis
Neurologic	No underlying causes
Nutritional / Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal / Electrolyte	No underlying causes
Rheum / Immune / Allergy	Amyloid | Ehlers-Danlos Syndrome Rheumatic Heart Disease | Systemic Lupus Erythematosus
Sexual	No underlying causes
Trauma	Trauma and motor vehicle accident
Urologic	No underlying causes
Miscellaneous	No underlying causes